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Titolo:
CELL-MEDIATED IMMUNE-RESPONSES TO E7 PEPTIDES OF HUMAN PAPILLOMAVIRUS(HPV) TYPE-16 ARE DEPENDENT ON THE HPV TYPE INFECTING THE CERVIX WHEREAS SEROLOGICAL REACTIVITY IS NOT TYPE-SPECIFIC
Autore:
KADISH AS; ROMNEY SL; LEDWIDGE R; TINDLE R; FERNANDO GJP; ZEE SY; VANRANST MA; BURK RD;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 QUEENSLAND UNIV TECHNOL,LIONS HUMAN IMMUNOL LABS BRISBANE AUSTRALIA
Titolo Testata:
Journal of General Virology
, volume: 75, anno: 1994,
parte:, 9
pagine: 2277 - 2284
SICI:
0022-1317(1994)75:<2277:CITEPO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL; INTRAEPITHELIAL NEOPLASIA; SYNTHETIC PEPTIDES; EPITOPES; CANCER; RISK; IDENTIFICATION; PROTEINS; ANTIBODIES; E6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Kadish et al., "CELL-MEDIATED IMMUNE-RESPONSES TO E7 PEPTIDES OF HUMAN PAPILLOMAVIRUS(HPV) TYPE-16 ARE DEPENDENT ON THE HPV TYPE INFECTING THE CERVIX WHEREAS SEROLOGICAL REACTIVITY IS NOT TYPE-SPECIFIC", Journal of General Virology, 75, 1994, pp. 2277-2284

Abstract

Forty-two women attending a colposcopy clinic for evaluation of abnormal cervical cytology and 13 normal controls were studied for the presence of lymphocyte proliferation (LP) cell-mediated immune (CMI) responses and serological reactivity to E7 peptides of human papillomavirustype 16 (HPV-16). HPV was typed by Southern blot hybridization of exfoliated cervicovaginal cell DNA. Positive LP responses (stimulation index greater than or equal to 5.0) to one or more E7 peptides were observed in 28.6% (12 of 42) of patients and 23.1% (three of 13) of controls. Of patients infected with HPV-16, -31 or -33, 63.6% (seven of 11) showed a positive LP response compared with 14.3% (two of 14) of womeninfected with other HPV types (P = 0.02), 17.6% (three of 17) negative for HPV (P = 0.02) and 23.1% (three of 13) of controls (HPV status unknown) (P = 0.05). C-terminal peptide 109 (amino acids 72 to 97) elicited positive LP responses in 45.4% (five of 11) of patients infected with HPV -16, -31 or -33 compared with 7.1% (one of 14) patients infected with other HPVs (P = 0.04), 5.9% (one of 17) of women negative forHPV (P = 0.02) and 7.7% (one of 13) of controls (P = 0.05). HPV-16 group-specific LP responses of borderline significance were also observed against E7 peptides 103, 105 and 108 (17-37, 37-54 and 62-80) (P = 0.07). ELISA reactivity (IgG) to E7 peptide 109 (72-97) was present in 77% (one of 13) of controls, 35.3% (six of 17) of HPV-negative patients, 42.9% (six of 14) of patients infected with other HPVs, and only 9.1% (one of 11) of patients infected with HPV-16, -31 or -33. CMI responses to C-terminal HPV-16 E7 peptide 109 (72-97) were thus significantly related to ongoing cervical infection with HPV-16 and closely related types, whereas serological reactivity to E7 peptides was not HPV type-specific.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:56:03