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Titolo:
A COMPARISON OF THE ANTINOCICEPTIVE EFFECTS OF IMIPRAMINE, TRAMADOL AND ANPIRTOLINE
Autore:
HUMMEL T; HUMMEL C; FRIEDEL I; PAULI E; KOBAL G;
Indirizzi:
UNIV ERLANGEN NURNBERG,DEPT EXPTL & CLIN PHARMACOL & TOXICOL,UNIV STR22 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DEPT NEUROL D-90154 ERLANGEN GERMANY
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 4, volume: 37, anno: 1994,
pagine: 325 - 333
SICI:
0306-5251(1994)37:4<325:ACOTAE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NASAL-MUCOSA; CHRONIC PAIN; EVOKED-POTENTIALS; CO2; ANTIDEPRESSANTS; BUPRENORPHINE; STIMULATION; SEROTONIN; RATS; CLOMIPRAMINE;
Keywords:
ANPIRTOLINE; TRAMADOL; IMIPRAMINE; EVENT-RELATED POTENTIAL; EEG; PAIN; NOCICEPTION; ANALGESIA; CHEMICAL STIMULATION; TRIGEMINAL NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
T. Hummel et al., "A COMPARISON OF THE ANTINOCICEPTIVE EFFECTS OF IMIPRAMINE, TRAMADOL AND ANPIRTOLINE", British journal of clinical pharmacology, 37(4), 1994, pp. 325-333

Abstract

1 The pain relieving properties of imipramine (100 mg orally), tramadol (150 mg orally), and anpirtoline (60 mg orally) were compared in 16healthy subjects in a cross-over, double-blind, randomized, and placebo-controlled study. Anpirtoline exhibits analgesia which is possibly mediated via serotoninergic pathways, whereas tramadol exerts its effects at opioid receptors. The pain-relieving effect of the tricyclic antidepressant imipramine may involve both serotoninergic and opioid mechanisms. 2 Chemo-somatosensory event-related potentials (CSSERP) were recorded after painful stimulation of the nasal mucosa with carbon dioxide. Subjects rated the perceived intensity of the stimuli by means of a visual analogue scale. In addition, acoustically evoked responses were recorded, the spontaneous EEG was analyzed in the frequency domain, the subjects' vigilance was assessed in a tracking task, and side effects of the drugs were monitored. 3 Anpirtoline and tramadol produced a decrease of both CSSERP amplitudes and subjective estimates of pain, the effects of the former compound being greater. In contrast, after administration of imipramine no change of CSSERP amplitudes could bedetected, whereas the subjective estimate of pain intensity decreasedsignificantly. This was accompanied by a significant decrease of arousal indicating that pain relief produced by acute administration of imipramine was primarily related to its sedation action. 4 The analgesicproperties of anpirtoline were demonstrated in man. Tramadol was characterized as a weak opioid analgesic. In contrast, imipramine appearedto produce its pain-relieving effects predominantly by non-specific actions. It is hypothesized that different analgesics may change ERP sources in a drug-specific manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:23:20