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Titolo:
NIKKOMYCIN-Z IS A SPECIFIC INHIBITOR OF SACCHAROMYCES-CEREVISIAE CHITIN SYNTHASE ISOZYME CHS3 IN-VITRO AND IN-VIVO
Autore:
GAUGHRAN JP; LAI MH; KIRSCH DR; SILVERMAN SJ;
Indirizzi:
AMER CYANAMID CO,DIV AGR RES,MOLEC GENET SCREEN DESIGN,POB 400 PRINCETON NJ 08543 AMER CYANAMID CO,DIV AGR RES,MOLEC GENET SCREEN DESIGN PRINCETON NJ 08543
Titolo Testata:
Journal of bacteriology
fascicolo: 18, volume: 176, anno: 1994,
pagine: 5857 - 5860
SICI:
0021-9193(1994)176:18<5857:NIASIO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE-TRANSPORT; CANDIDA-ALBICANS; CALCOFLUOR WHITE; SEPTUM FORMATION; CELL-CYCLE; POLYOXIN-D; YEAST; SYNTHETASE; ENZYME; GENES;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Gaughran et al., "NIKKOMYCIN-Z IS A SPECIFIC INHIBITOR OF SACCHAROMYCES-CEREVISIAE CHITIN SYNTHASE ISOZYME CHS3 IN-VITRO AND IN-VIVO", Journal of bacteriology, 176(18), 1994, pp. 5857-5860

Abstract

Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin synthase isozymes and growth assays with isozyme mutants were used to demonstrate that nikkomycin Z is a selective inhibitor of chitin synthase 3. Theresistance of chitin synthase 2 to nikkomycin Z in vitro is likely responsible for the poor activity of this antibiotic against Saccharomyces cerevisiae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:07:14