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Titolo:
EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN DELAYED-TYPE HYPERSENSITIVITY REACTIONS IN THE SKIN
Autore:
YU XH; BARNHILL RL; GRAVES DT;
Indirizzi:
BOSTON UNIV,SCH GRAD DENT,DEPT ORAL BIOL,W-215,700 ALBANY ST BOSTON MA 02118 BOSTON UNIV,SCH GRAD DENT,DEPT ORAL BIOL BOSTON MA 02118 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT PATHOL,DIV DERMATOPATHOL BOSTON MA 02115
Titolo Testata:
Laboratory investigation
fascicolo: 2, volume: 71, anno: 1994,
pagine: 226 - 235
SICI:
0023-6837(1994)71:2<226:EOMCPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR LEUKOCYTES; CHEMOTACTIC PROTEIN; ENDOTHELIAL-CELLS; CYTOKINE FAMILY; IDENTIFICATION; PURIFICATION; LESIONS;
Keywords:
CHEMOTAXIS; AUTOIMMUNE; SPONGIOTIC DERMATITIS; LICHENOID DERMATITIS; LUPUS ERYTHEMATOSUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
X.H. Yu et al., "EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN DELAYED-TYPE HYPERSENSITIVITY REACTIONS IN THE SKIN", Laboratory investigation, 71(2), 1994, pp. 226-235

Abstract

BACKGROUND: Monocyte chemoattractant Protein-1 (MCP-1) is a potent chemotactic factor for monocytes. Because many inflammatory dermatoses are characterized by mononuclear cell infiltrates, it is reasonable to postulate that MCP-1 might be involved in their pathogenesis. To date,no in vivo studies have been published concerning the expression of MCP-1 in this context. The aim of this study was to elucidate the expression of MCP-1 in human inflammatory skin diseases which are thought to involve delayed type hypersensitivity reactions. EXPERIMENTAL DESIGN: Expression of MCP-1 was examined in normal skin and three classes ofinflammatory skin reactions by immunohistochemistry experiments utilizing a monospecific MCP-1 antiserum. The distribution of monocytes/macrophages and T lymphocytes was determined by immunohistochemistry using antibodies to specific cell surface markers. RESULTS: Immunostainingwith MCP-1 antiserum demonstrated strong MCP-1 expression in lichenoid dermatitis, dermal hypersensitivity reactions, and spongiotic dermatitis. In contrast, normal skin showed minimal MCP-1 expression in the dermis. The cell types displaying MCP-1 expression were endothelial cells of dermal microvessels that were surrounded by lymphocytic infiltrates and monocytes/macrophages at the periphery of the perivascular infiltrates, Occasionally, MCP-1-positive mononuclear cells were presentboth in the infiltrates and in a diffuse pattern in the surrounding dermis. Keratinocytes were found to produce MCP-1 constitutively in normal skin and in inflamed conditions. The pattern of MCP-1 expression was similar to the pattern observed for monocyte/macrophage distribution, whereas the pattern of MCP-1 expression was different from the pattern of T lymphocyte distribution. CONCLUSIONS: We observed an enhancedexpression of MCP-1 in inflammatory skin conditions. The expression of MCP-1 provides a mechanistic explanation for the increased recruitment of monocytes/macrophages in cell-mediated immune response such as delayed type hypersensitivity reactions in the skin.

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Documento generato il 25/09/20 alle ore 00:34:57