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Titolo:
EXPRESSION OF MAMMALIAN PROTEIN-KINASE-C IN SCHIZOSACCHAROMYCES-POMBE- ISOTYPE-SPECIFIC INDUCTION OF GROWTH ARREST, VESICLE FORMATION, ANDENDOCYTOSIS
Autore:
GOODE NT; HAJIBAGHERI MAN; WARREN G; PARKER PJ;
Indirizzi:
IMPERIAL CANC RES FUND,PROT PHOSPHORYLAT LAB LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,PROT PHOSPHORYLAT LAB LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,ELECTRON MICROSCOPY UNIT LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,CELL BIOL LAB LONDON WC2A 3PX ENGLAND
Titolo Testata:
Molecular biology of the cell
fascicolo: 8, volume: 5, anno: 1994,
pagine: 907 - 920
SICI:
1059-1524(1994)5:8<907:EOMPIS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR RECEPTOR; FISSION YEAST; SUBSTRATE-SPECIFICITY; MOLECULAR HETEROGENEITY; TRANSFERRIN RECEPTOR; DOWN-REGULATION; PHOSPHORYLATION; ACTIVATION; ZETA; BOVINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
N.T. Goode et al., "EXPRESSION OF MAMMALIAN PROTEIN-KINASE-C IN SCHIZOSACCHAROMYCES-POMBE- ISOTYPE-SPECIFIC INDUCTION OF GROWTH ARREST, VESICLE FORMATION, ANDENDOCYTOSIS", Molecular biology of the cell, 5(8), 1994, pp. 907-920

Abstract

Mammalian protein kinase C (PKC) isotypes elicit a number of effects on expression in Schizosaccharomyces pombe. A small decrease in growthrate results from PKC-gamma expression, and treatment of these cells with phorbol esters leads to marked growth inhibition and vesicle formation. PKC-delta and -eta expression causes growth inhibition and vesiculation, and the magnitude of both of these effects is increased by phorbol esters. In contrast, PKC-epsilon expression produces growth inhibition but no vesicle accumulation, and this effect is not responsiveto phorbol ester. Finally, PKC-zeta has no observable effect. Thus, isotype-specific biological effects are observed. The accumulation of vesicles correlates with phorbol ester-dependent growth inhibition and occurs only with expression of those isotypes that downregulate in response to phorbol esters in these cells. Antibodies against mammalian clathrin light chain la identified clathrin-coated vesicles and up-regulation of clathrin expression in those cells where vesicles accumulate; the increased vesicular traffic includes an element of endocytosis. Thus expression of specific mammalian PKC isotypes up-regulates endocytosis in S. pombe, providing a likely explanation for PKC-mediated receptor internalization in higher eukaryotes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:08:04