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Titolo:
CEREBRAL BLOOD-FLOW CHANGES INDUCED BY A CHRONIC TREATMENT WITH CAPTOPRIL IN PREVIOUSLY UNTREATED ELDERLY HYPERTENSIVE SUBJECTS
Autore:
LARRUE V; DUPUI P; PAVYLETRAON A; ALLAVOINE T; GERAUD G; BES A;
Indirizzi:
CHU RANGUEIL,SERV NEUROL,HEMODYNAMIC CEREBRALE LAB,1 AVE JEAN POULHESF-31054 TOULOUSE FRANCE FAC MED TOULOUSE,PHYSIOL LAB F-31062 TOULOUSE FRANCE RHONE POULENC RORER,THERAPLIX LAB F-75640 PARIS 13 FRANCE
Titolo Testata:
Archives des maladies du coeur et des vaisseaux
fascicolo: 8, volume: 87, anno: 1994,
pagine: 997 - 1000
SICI:
0003-9683(1994)87:8<997:CBCIBA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
FRE
Soggetto:
ANGIOTENSIN CONVERTING ENZYME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
V. Larrue et al., "CEREBRAL BLOOD-FLOW CHANGES INDUCED BY A CHRONIC TREATMENT WITH CAPTOPRIL IN PREVIOUSLY UNTREATED ELDERLY HYPERTENSIVE SUBJECTS", Archives des maladies du coeur et des vaisseaux, 87(8), 1994, pp. 997-1000

Abstract

Cerebral blood flow (CBF) was measured in 13 subjects (4 men and 9 women, mean age +/- SD = 63 +/- 7) with moderate, uncomplicated and untreated hypertension and 11 normotensive subjects (6 men and 5 women, mean age +/- SD = 66 +/- 5). A second CBF measurement was performed in hypertensive subjects after a 60 days randomized double blind treatmentwith either captopril, 75 mg a day (n = 8) or placebo (n = 5). CBF was quantified using the Xe-133 inhalation technic and 16 stationary detectors by hemisphere. Comparison of CBF values between hypertensive subjects before treatment and normotensive subjects demonstrated a decrease of CBF in the hypertensive group (49 +/- 9 vs 72 +/- 14 ml/100 g/min ; p < 0.001). After the trial the results in the captopril group showed a significant fall in systolic (p < 0.001) and diastolic (p < 0.05) blood presure and a significant increase in CBF (60 +/- 14 vs 49 +/- 11 ml/100 g/min ; p < 0.05). In the placebo group there was no change in blood pressure and CBF (Table). [GRAPHICS] Our results demonstrate a decrease in CBF of uncomplicated and untreated elderly hypertensive subjects. This decrease is reversible under chronic treatment with captopril.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:10:37