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Titolo:
EFFECT OF THE PLATELET-ACTIVATING-FACTOR ANTAGONIST BN52021 IN RABBITS - ROLE IN GENTAMICIN-NEPHROTOXICITY
Autore:
HANSLIK T; BLANCHET F; NOCHY D; PIROTZKY E; GUILMARD C; SETA N; CARBON C;
Indirizzi:
CHU BICHAT,INSERM,U13 F-75018 PARIS FRANCE CHU BICHAT,EXPLORAT FONCT LAB F-75018 PARIS FRANCE HOP BROUSSAIS,ANATOMOPATHOL LAB F-75674 PARIS FRANCE INST HENRI BEAUFOUR LES ULIS FRANCE CHU BICHAT,BIOCHIM LAB F-75018 PARIS FRANCE
Titolo Testata:
Toxicology and applied pharmacology
fascicolo: 1, volume: 128, anno: 1994,
pagine: 111 - 115
SICI:
0041-008X(1994)128:1<111:EOTPAB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOGLYCOSIDE NEPHROTOXICITY; RAT; NETILMICIN; CELLS; PAF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Hanslik et al., "EFFECT OF THE PLATELET-ACTIVATING-FACTOR ANTAGONIST BN52021 IN RABBITS - ROLE IN GENTAMICIN-NEPHROTOXICITY", Toxicology and applied pharmacology, 128(1), 1994, pp. 111-115

Abstract

Platelet activating factor (PAF) is an ubiquitous phospholipid that acts as a mediator of numerous pathophysiological conditions, includingdrug nephrotoxicity. Aminoglycosides are potent antibiotics but theiruse is limited by their nephrotoxic potential. We assumed that PAF could participate in inducing gentamicin nephrotoxicity, and we used thePAF antagonist BN52021 to test this hypothesis. We studied renal glomerular and tubular function by clearance techniques and renal histology in four groups of New Zealand male rabbits treated for 7 days with isotonic saline, BN52021, gentamicin, or gentamicin + BN52021. BN52021 alone reduced only fractional excretions (FE) of sodium and chloride, without modifying the other parameters studied. Renal histology was not altered. Gentamicin reduced glomerular filtration rate and renal plasma flow. Free water clearance was not modified. Sodium, potassium, chloride, calcium, and magnesium FEs were raised. Renal histology showeda massive and diffuse tubular necrosis. BN52021 did not modify gentamicin glomerular, tubular, or histopathological alterations. These datasuggest that PAF might physiologically affect tubular function in NewZealand male rabbits, increasing sodium and chloride excretions, and in a minute manner, potassium, calcium, and magnesium excretions. Under our experimental conditions, there was no evidence for a role of PAFin gentamicin nephrotoxicity. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:58:26