Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTERLEUKIN-1 AND INTERFERON-ALPHA AUGMENT INTERLEUKIN-2 (IL-2) PRODUCTION BY DISTINCT MECHANISMS AT THE IL-2 MESSENGER-RNA LEVEL
Autore:
HOLAN V; DAO T; KOSAROVA M; LIPOLDOVA M; MINOWADA J;
Indirizzi:
ACAD SCI CZECH REPUBL,INST MOLEC GENET,FLEMINGOVO 2 CR-16637 PRAGUE 6CZECH REPUBLIC HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR OKAYAMA 702 JAPAN
Titolo Testata:
Cellular immunology
fascicolo: 2, volume: 157, anno: 1994,
pagine: 549 - 555
SICI:
0008-8749(1994)157:2<549:IAIAI(>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; MESSENGER-RNA; GENE-EXPRESSION; CYCLOSPORIN-A; GROWTH-FACTOR; LYMPHOCYTES; LYMPHOKINE; PATHWAYS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
V. Holan et al., "INTERLEUKIN-1 AND INTERFERON-ALPHA AUGMENT INTERLEUKIN-2 (IL-2) PRODUCTION BY DISTINCT MECHANISMS AT THE IL-2 MESSENGER-RNA LEVEL", Cellular immunology, 157(2), 1994, pp. 549-555

Abstract

The production of interleukin-2 (IL-2) by phytohemaglutinin (PHA)-stimulated cells of human leukemia T cell line MOLT-16 can be significantly increased by interleukin-1 (IL-1) or interferon-alpha (IFN-alpha). The enhancing effect of IL-1 and IFN-alpha on IL-2 production was studied at the IL-2 mRNA level. We show that IL-1 enhances considerably and transiently, with the maximum level between 1 and 2 hr after stimulation, the expression of IL-2 mRNA in the PHA-stimulated cells. The level of IL-2 mRNA declined rapidly within 4 to 6 hr after stimulation inboth PHA- and PHA plus IL1-stimulated cell cultures. On the contrary,IFN-alpha does not elevate the level of IL-2 mRNA above the level in PHA-stimulated cultures, but maintains an enhanced level of IL-2 mRNA in the activated cells for more than 6 hr after stimulation. These observations correlate well with the kinetics of IL-2 protein production into the culture media. The results thus suggest that IL-1 and IFN-alpha may exert an enhancing effect on IL-2 production by distinct mechanisms. In addition, none of the five other lymphokines tested (i.e., IL-2, IL-3, IL-4, IL-5, and IL-6) had any significant effect on IL-2 mRNA expression in the activated MOLT-16 cells. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:10:19