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Titolo:
INTRAAMYGDALA KINASE INHIBITORS DISRUPT RETENTION OF A LEARNED AVOIDANCE-RESPONSE IN RATS
Autore:
WALKER DL; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,102 GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 176, anno: 1994,
pagine: 255 - 258
SICI:
0304-3940(1994)176:2<255:IKIDRO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROTEIN-KINASE; C INHIBITORS; POLYMYXIN-B; CALMODULIN; INDUCTION; CA1; ANTAGONISTS; ACQUISITION; MAINTENANCE;
Keywords:
AMYGDALA; INHIBITORY AVOIDANCE; KINASE; LEARNING; MEMORY; NPC 15437; PROTEIN KINASE C; PMXB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Walker e P.E. Gold, "INTRAAMYGDALA KINASE INHIBITORS DISRUPT RETENTION OF A LEARNED AVOIDANCE-RESPONSE IN RATS", Neuroscience letters, 176(2), 1994, pp. 255-258

Abstract

To assess the involvement of intra-amygdala kinase activity in aversively motivated learning, rats received intracranial injections of polymixin B sulfate (PMXB) - a protein kinase C (PKC) and calcium/calmodulin-dependent kinase II inhibitor - immediately after inhibitory avoidance training. When tested 48 h later, retention was significantly impaired relative to vehicle-injected controls. Delayed injections (2 h posttraining) and injections made dorsal to the amygdala were ineffective. Immediate posttraining injections of the more selective PKC inhibitor, NPC 15437, also impaired retention. These results suggest that intra-amygdala protein phosphorylation must occur soon after training forlearned avoidance responses to be successfully retained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:26:08