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Titolo:
DILATATION OF CEREBRAL MICROVESSELS MEDIATED BY ENDOTHELIN ET(B) RECEPTOR AND NITRIC-OXIDE IN CATS
Autore:
KOBARI M; FUKUUCHI Y; TOMITA M; TANAHASHI N; KONNO S; TAKEDA H;
Indirizzi:
KEIO UNIV,SCH MED,DEPT NEUROL,SHINJUKU KU,35 SHINANOMACHI TOKYO 160 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 176, anno: 1994,
pagine: 157 - 160
SICI:
0304-3940(1994)176:2<157:DOCMMB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETB RECEPTOR; BLOOD-FLOW; CIRCULATION; MICROCIRCULATION; RELAXATION; MODULATION; PRESSURE; IRL-1620; AGONIST; POTENT;
Keywords:
CEREBRAL BLOOD VOLUME; CEREBRAL MICROVESSEL; ENDOTHELIN RECEPTOR; ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF); IRL1620; N-G-MONOMETHYL-L-ARGININE (L-NMMA); NITRIC OXIDE; PHOTOELECTRIC METHOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Kobari et al., "DILATATION OF CEREBRAL MICROVESSELS MEDIATED BY ENDOTHELIN ET(B) RECEPTOR AND NITRIC-OXIDE IN CATS", Neuroscience letters, 176(2), 1994, pp. 157-160

Abstract

The functional role of the endothelin (ET)(B) receptor in the cerebral microvessels was examined in seven anesthetized cats. The effects ofintracarotidly injected IRL1620, st selective ET(B) receptor agonist,on the cerebral blood volume (CBV) in the cortex were examined by a photoelectric method. CBV reflects the cumulative dimensions of the cerebral microvessels. High doses of IRL1620 (0.1-1 nmol/kg) elicited a transient fan in CBV, followed by a marked and dose-related increase ofCBV (P < 0.01). The CBV increase was significantly inhibited (P < 0.01) by simultaneous administration of 0.35 mg/kg/min N-G-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis. The marked, but transient, depressor effect of IRL1620 was also attenuated (P < 0.01) by L-NMMA. The ET(B) receptor subtype and production of nitric oxide, probably in the endothelium, mediate the vasodilatory action of ETin the cerebral microvessels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:36:04