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Titolo:
ANTIHERPESVIRUS ACTIVITY OF THE COMBINATION OF 5-IODO-2'-DEOXYCYTIDINE WITH METHOTREXATE - AN IN-VITRO AND IN-VIVO STUDY
Autore:
CREMONESI C; SCARPINI C; BIANCHI R; RADAELLI A; GIMELLI M; MORGHEN CD;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,DEPT PHARMACOL I-20129 MILAN ITALY UNIV MILAN,CNR,CTR CYTOPHARMACOL I-20129 MILAN ITALY UNIV MILAN,CNR,CTR STUDY RELAT STRUCT & CHEM REACT I-20129 MILAN ITALY UNIV MILAN,INST PHARMACOL SCI I-20129 MILAN ITALY
Titolo Testata:
Antiviral chemistry & chemotherapy
fascicolo: 5, volume: 5, anno: 1994,
pagine: 283 - 289
SICI:
0956-3202(1994)5:5<283:AAOTCO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS; VIRAL GENE-EXPRESSION; INFECTED HELA-CELLS; 5-HALOGENATED ANALOGS; TRANSFORMED-CELLS; ANTIVIRAL AGENTS; DNA; DEOXYCYTIDINE; KINASE; METHYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Cremonesi et al., "ANTIHERPESVIRUS ACTIVITY OF THE COMBINATION OF 5-IODO-2'-DEOXYCYTIDINE WITH METHOTREXATE - AN IN-VITRO AND IN-VIVO STUDY", Antiviral chemistry & chemotherapy, 5(5), 1994, pp. 283-289

Abstract

We evaluated the in vitro and in vivo antiviral activity of the deoxyribonucleoside analogue 5-iodo-2'-deoxycytidine (IDC) combined with the dihydrofolate reductase inhibitor methotrexate (MTX) on herpes simplex virus types 1 and 2 (HSV-1, HSV-2). The IDC-MTX combination synergistically inhibited HSV-1 and HSV-S replication in vitro at concentrations that did not reduce cellular viability and was very effective in reducing the severity of cutaneous lesions in the experimental guinea pig model in vivo. The antiviral activity of the IDC-MTX combination inguinea pigs was also compared with that of acyclovir and was demonstrated to be higher.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:43:08