Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POSSIBLE MECHANISMS OF AUTOANTIBODY PRODUCTION AND THE CONNECTION OF VIRAL-INFECTIONS IN HUMAN AUTOIMMUNE-DISEASES
Autore:
YAMAMOTO K;
Indirizzi:
ST MARIANNA UNIV,SCH MED,INST MED SCI,DIV RHEUMATOL & MOLEC IMMUNOL,MIYAMAE KU,2-16-1 SUGAO KAWASAKI 216 JAPAN UNIV TOKYO,FAC MED,DEPT MED & PHYS THERAPY TOKYO 113 JAPAN
Titolo Testata:
Tohoku Journal of Experimental Medicine
fascicolo: 1, volume: 173, anno: 1994,
pagine: 75 - 82
SICI:
0040-8727(1994)173:1<75:PMOAPA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL NUCLEAR RIBONUCLEOPROTEIN; DNA TOPOISOMERASE-I; B-CELL EPITOPE; ANTINUCLEAR ANTIBODIES; T-CELLS; ANTIGEN; PROTEIN; VIRUS; IDENTIFICATION; INDUCTION;
Keywords:
AUTOANTIBODY; AUTOIMMUNE DISEASE; EPITOPE MAPPING; MOLECULAR MIMICRY; VIRAL INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Yamamoto, "POSSIBLE MECHANISMS OF AUTOANTIBODY PRODUCTION AND THE CONNECTION OF VIRAL-INFECTIONS IN HUMAN AUTOIMMUNE-DISEASES", Tohoku Journal of Experimental Medicine, 173(1), 1994, pp. 75-82

Abstract

The presence of autoantibodies is a characteristic phenomenon in an autoimmune disease. In order to investigate the mechanisms of the autoantibody production, me have performed epitope mappings of the autoantigens. It thus was found that there were multiple epitopes on an autoantigen molecule, and a serum from a patient with an autoimmune disease usually recognizes these multiple epitopes simultaneously, suggesting that autoantibodies are ultimately produced by an antigen-driven mechanism. However, other evidence suggests that tolerance to a self antigen is rather tightly maintained and a simple antigen-driven mechanism cannot easily take place. Based on the results of epitope mappings, it appears that there is a major or a usually recognized epitope on almost every autoantigen molecule. Some patients only recognize this epitope. It is unlikely that only a single epitope can be recognized if a large molecule is immunized to the host. Therefore, the recognition of this universal epitope may play some roles in the induction of the autoantibody production. In fact, some of these epitopes have sequences homologous to those of viral proteins. Thus, it is possible that an immune response to a certain virus might induce by molecular mimicry the recognition of an autoantigen. Possible mechanisms following this molecular mimicry that may induce antigen-driven autoantibody production are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:45:39