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Titolo:
G-PROTEIN GAMMA-7 SUBUNIT IS SELECTIVELY EXPRESSED IN MEDIUM-SIZED NEURONS AND DENDRITES OF THE RAT NEOSTRIATUM
Autore:
WATSON JB; COULTER PM; MARGULIES JE; DELECEA L; DANIELSON PE; ERLANDER MG; SUTCLIFFE JG;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT MOLEC BIOL,10666 N TORREY PINES RD LA JOLLA CA 92037 SCRIPPS CLIN & RES INST,DEPT MOLEC BIOL LA JOLLA CA 92037 UNIV CALIF LOS ANGELES,SCH MED,MENTAL RETARDAT RES CTR,DEPT PSYCHIAT & BEHAV SCI LOS ANGELES CA 90024
Titolo Testata:
Journal of neuroscience research
fascicolo: 1, volume: 39, anno: 1994,
pagine: 108 - 116
SICI:
0360-4012(1994)39:1<108:GGSISE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
D1 DOPAMINE RECEPTOR; MUSCARINIC K+-CHANNEL; BETA-GAMMA; PHOSPHOLIPASE-C; MESSENGER-RNA; ALPHA-SUBUNIT; INSITU HYBRIDIZATION; ADENYLYL CYCLASE; GENE-EXPRESSION; CDNA CLONING;
Keywords:
G PROTEIN; STRIATUM; SUBTRACTIVE HYBRIDIZATION; IN SITU HYBRIDIZATION; MESSENGER-RNA TRANSLOCATION; SIGNAL TRANSDUCTION; ADENYLYL CYCLASE; DOPAMINE RECEPTORS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Watson et al., "G-PROTEIN GAMMA-7 SUBUNIT IS SELECTIVELY EXPRESSED IN MEDIUM-SIZED NEURONS AND DENDRITES OF THE RAT NEOSTRIATUM", Journal of neuroscience research, 39(1), 1994, pp. 108-116

Abstract

We used subtractive hybridization to isolate clones of gamma 7, a 68 residue G-protein gamma subunit. Northern blotting and in situ hybridization reveal that the gamma 7 subunit mRNA is expressed primarily in medium-sized neurons of the neostriatum and nucleus accumbens and neurons of the olfactory tubercle, and at low levels in the dentate gyrus of the hippocampal formation and laminae II-III, and V of the neocortex. The gamma 7 mRNA is translocated into dendrites of neurons in the neostriatum and the dentate gyrus of the hippocampus. gamma 7 is expressed at relatively very low concentrations in peripheral tissues. The selective pattern of gamma 7 expression within the brain is highly reminiscent of those of the striatum-enriched adenylyl cyclase AC(ST), dopamine receptors, and the alpha subunit of G(olf), suggesting that, in striatum, gamma 7 may be a subunit of a G(olf alpha)-containing G protein that couples dopamine receptors selectively to AC(ST). (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:41:49