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Titolo:
TREATMENT OF PATIENTS WITH IRRESECTABLE LIVER METASTASES FROM COLORECTAL-CANCER BY CHEMO-OCCLUSION WITH DEGRADABLE STARCH MICROSPHERES
Autore:
CIVALLERI D; PECTOR JC; HAKANSSON L; ARNAUD JP; DUEZ N; BUYSE M;
Indirizzi:
UNIV GENOA,CHIRURG CLIN 1,EUROPEAN ORG RES TREATMENT CANC,GASTROINTESTINAL GRP I-16132 GENOA ITALY INST JULES BORDET BRUSSELS BELGIUM LINKOPING UNIV LINKOPING SWEDEN CTR MEDICOCHIRURG & OBSTET STRASBOURG FRANCE EUROPEAN ORG RES TREATMENT CANC,CTR DATA BRUSSELS BELGIUM
Titolo Testata:
British Journal of Surgery
fascicolo: 9, volume: 81, anno: 1994,
pagine: 1338 - 1341
SICI:
0007-1323(1994)81:9<1338:TOPWIL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ARTERIAL EMBOLIZATION; IMPROVED REGIONAL SELECTIVITY; PROSPECTIVE RANDOMIZED TRIAL; INFUSION CHEMOTHERAPY; TUMOR UPTAKE; FLUORODEOXYURIDINE; PHARMACOKINETICS; 5-FLUOROURACIL; CARCINOMA; FLOXURIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D. Civalleri et al., "TREATMENT OF PATIENTS WITH IRRESECTABLE LIVER METASTASES FROM COLORECTAL-CANCER BY CHEMO-OCCLUSION WITH DEGRADABLE STARCH MICROSPHERES", British Journal of Surgery, 81(9), 1994, pp. 1338-1341

Abstract

Chemo-occlusion of the liver increases the tumour concentration of drugs. Thirty-nine patients with colorectal liver metastases received a monthly bolus administration of mitomycin C (10 mg/m(2) on day 1) plusa continuous infusion of 5-fluorouracil (500 mg/m(2) daily from days 1 to 5). Drugs were given via both portal (one-third of the dose) and arterial (two-thirds) routes to control large and small metastases. Arterially administered mitomycin C was mixed with individualized doses of degradable starch microspheres. In 16 patients treatment was not started or was interrupted early because of arterial or portal catheter problems. In 23 patients who received two or more cycles of treatment the mean(s.d.) microsphere dose was 835(399) mg. Toxicity was mild, consisting mainly of pain. Five complete and five partial responses wereseen, and six patients had stable disease. The median time to progression and length of survival were 6 and 16 months respectively. The relatively high rates of complete and overall response in hypovascular tumours (six of 12 lesions) may support the rationale of chemo-occlusion,

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 14:49:26