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Titolo:
ADVERSE-EFFECTS OF ZOTEPINE AND THEIR RELATIONSHIP TO SERUM CONCENTRATIONS OF THE DRUG AND PROLACTIN
Autore:
KONDO T; OTANI K; ISHIDA M; TANAKA O; KANEKO S; FUKUSHIMA Y;
Indirizzi:
HIROSAKI UNIV,SCH MED,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN
Titolo Testata:
Therapeutic drug monitoring
fascicolo: 2, volume: 16, anno: 1994,
pagine: 120 - 124
SICI:
0163-4356(1994)16:2<120:AOZATR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; SCHIZOPHRENIC-PATIENTS; PLASMA-CONCENTRATIONS; HALOPERIDOL; CHLORPROMAZINE; SYMPTOMS; STATE;
Keywords:
ZOTEPINE; ADVERSE EFFECTS; SERUM CONCENTRATIONS; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T. Kondo et al., "ADVERSE-EFFECTS OF ZOTEPINE AND THEIR RELATIONSHIP TO SERUM CONCENTRATIONS OF THE DRUG AND PROLACTIN", Therapeutic drug monitoring, 16(2), 1994, pp. 120-124

Abstract

Adverse effects of zotepine, an antipsychotic drug, and their relationship to serum concentrations of the drug and prolactin were investigated in 28 schizophrenic in-patients. The daily dose was 100 mg during the first week and 200 mg during the next 3 weeks. Adverse effects were evaluated by the UKU Side Effect Rating Scale (21 items). The mean (/-SD) total UKU score at the end of the study was 3.1 +/- 2.5, indicating mild adverse effects. The scores of psychic adverse effects at 2 weeks and total adverse effects at 3 and 4 weeks were significantly higher in nonresponders than in responders (p < 0.05). Furthermore, there was a significant inverse correlation between percent improvement intotal Brief Psychiatric Rating Scale (BPRS) scores and total UKU scores at 4 weeks (p < 0.05). These results suggest a relationship betweenpoor clinical response and increased adverse effects during zotepine treatment. Only the scores of akathisia at 2 weeks showed a significantly positive correlation with serum zotepine concentrations (p < 0.05). No correlation was found between prolactin response and neurologicaladverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:48:29