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Titolo:
BRIDGING THE GAP BETWEEN BASIC AND CLINICAL ELECTROPHYSIOLOGY - WHAT CAN BE LEARNED FROM MONOPHASIC ACTION-POTENTIAL RECORDINGS
Autore:
FRANZ MR;
Indirizzi:
VET ADM MED CTR,DIV CARDIOL,50 IRVING ST NW WASHINGTON DC 20422 GEORGE WASHINGTON UNIV,SCH MED,DIV CARDIOL WASHINGTON DC 00000 GEORGE WASHINGTON UNIV,SCH MED,DEPT CLIN PHARMACOL WASHINGTON DC 00000
Titolo Testata:
Journal of cardiovascular electrophysiology
fascicolo: 8, volume: 5, anno: 1994,
pagine: 699 - 710
SICI:
1045-3873(1994)5:8<699:BTGBBA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-EXCITATION FEEDBACK; ARRHYTHMIA SUPPRESSION TRIAL; CONGESTIVE-HEART-FAILURE; MYOCARDIAL-ISCHEMIA; POSTREPOLARIZATION REFRACTORINESS; VENTRICULAR ARRHYTHMIAS; ANTIARRHYTHMIC AGENTS; CATHETER TECHNIQUE; VALSALVA MANEUVER; DE-POINTES;
Keywords:
MONOPHASIC ACTION POTENTIALS; ANTIARRHYTHMIC DRUGS; USE DEPENDENCY; AFTERDEPOLARIZATIONS; VENTRICULAR FIBRILLATION; CATHETER ABLATION; MYOCARDIAL ISCHEMIA; MECHANOELECTRICAL FEEDBACK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Franz, "BRIDGING THE GAP BETWEEN BASIC AND CLINICAL ELECTROPHYSIOLOGY - WHAT CAN BE LEARNED FROM MONOPHASIC ACTION-POTENTIAL RECORDINGS", Journal of cardiovascular electrophysiology, 5(8), 1994, pp. 699-710

Abstract

With rapid advances occuring in both basic and clinical electrophysiology, the gap between the two disciplines appears to be widening rather than narrowing. In most instances, we cannot apply the knowledge derived from cellular studies directly to clinical practice. Monophasic action potential (MAP) recording by contact electrode technique allows us to measure basic electrophysiological phenomena in the human heart and thus provides an important bridge between basic and clinical electrophysiology. MAP recordings produce the time course of cellular repolarization during cycle length changes and antiarrhythmic drug administration, lending insights into use dependency and reverse use dependency of antiarrhythmic drug effects in the clinical electrophsiology laboratory. The ability to deliver electrical stimuli at the MAP recordingsite further allows one to investigate drug-induced postrepolarization refractoriness. MAP recordings provide precise local activation times, important for mapping of abnormal ventricular activation, and detect areas of abnormal repolarization due to ischemia or scarring. MAP recordings are uniquely suited to detect early and delayed afterdepolarizations in the human heart, thereby helping to unravel the arrhythmia mechanisms in the long QT syndrome. By embedding the MAP electrode in a radiofrequency electrode, arrhythmogenic foci may be both detected and ablated. In many instances, MAP recordings are more accurate than ECG tracings in defining and distinguishing ventricular fibrillation and ventricular tachycardia. This can be of clinical importance during testing of the implantable cardioverter/defibrillator. An area of growing interest is stretch-activated arrhythmias. Here, MAP recordings areof particular value because no other method is available to record mechanically induced electrophysiological changes in the vigorously beating heart. It can be expected that MAP recordings will, in the future,provide this important bridge between ''cell and bedside'' also in atrial tachyarrhythmias, such as in atriaI fibrillation and flutter.

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Documento generato il 24/11/20 alle ore 22:48:47