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Titolo:
SEQUENTIAL ESTIMATION OF LINKAGE BETWEEN PCR-GENERATED MARKERS AND A TARGET GENE EMPLOYING STEPWISE BULKED ANALYSIS
Autore:
RONIN YI; KOROL AB; FAHIMA T; KIRZHNER VM; NEVO E;
Indirizzi:
UNIV HAIFA,INST EVOLUT,MT CARMEL IL-31905 HAIFA ISRAEL
Titolo Testata:
Biometrics
fascicolo: 4, volume: 52, anno: 1996,
pagine: 1428 - 1439
SICI:
0006-341X(1996)52:4<1428:SEOLBP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILDEW RESISTANCE GENES; NEAR-ISOGENIC LINES; QUANTITATIVE TRAIT; DISEASE-RESISTANCE; MOLECULAR MARKERS; DNA MARKERS; IDENTIFICATION; TOMATO; POPULATIONS; PRIMERS;
Keywords:
BIAS; BULKED ANALYSIS; CENSORED ESTIMATION; CLOSE LINKAGE; MULTIPLE MARKERS; PCR; SEQUENTIAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y.I. Ronin et al., "SEQUENTIAL ESTIMATION OF LINKAGE BETWEEN PCR-GENERATED MARKERS AND A TARGET GENE EMPLOYING STEPWISE BULKED ANALYSIS", Biometrics, 52(4), 1996, pp. 1428-1439

Abstract

PCR-based markers are used for targeting plant genes. However, mapping these markers requires laborious and expensive analysis of individual genotypes. We propose here a sequential procedure for fine mapping of PCR markers relative to a target gene. Stepwise bulked analysis is employed to get a censored estimation of the recombination rate. The sequential estimation is compared to fixed sample size design. In both cases, the proposed procedure can achieve a substantial reduction in the number of PCR runs (up to 90-97% for close linkage) as compared to the standard individual-by-individual analysis.

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Documento generato il 25/09/20 alle ore 06:35:29