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Titolo:
DIFFERENT EXPRESSION OF BETA-N-ACETYLHEXOSAMINIDASE IN MOUSE-TISSUES
Autore:
DELLAFAZIA MA; BECCARI T; SERVILLO G; VIOLAMAGNI MP; ORLACCHIO A;
Indirizzi:
UNIV PERUGIA,DIPARTIMENTO BIOL CELLULARE & MOLEC,VIA GIOCHETTO I-06126 PERUGIA ITALY UNIV PERUGIA,DIPARTIMENTO BIOL CELLULARE & MOLEC,VIA GIOCHETTO I-06126 PERUGIA ITALY UNIV PERUGIA,POLICLIN MONTELUCE,IST PATOL GEN I-06126 PERUGIA ITALY
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 199, anno: 1994,
pagine: 1341 - 1346
SICI:
0006-291X(1994)199:3<1341:DEOBIM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXOSAMINIDASE ALPHA-CHAIN; EXTENSIVE HOMOLOGY; SEQUENCE-ANALYSIS; LYSOSOMAL-ENZYME; SUBUNIT; EPIDIDYMIS; 6-SULFATE; PROTEIN; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Dellafazia et al., "DIFFERENT EXPRESSION OF BETA-N-ACETYLHEXOSAMINIDASE IN MOUSE-TISSUES", Biochemical and biophysical research communications, 199(3), 1994, pp. 1341-1346

Abstract

The expression of genes encoding for the alpha and beta-subunits of the lysosomal enzyme beta-N-acetylhexosaminidase was investigated in different mouse tissues. It was found, using fluorogenic substrates,thatthe amounts of alpha and beta subunits were not the same in differenttissues: alpha-subunit was more abundant in the brain, beta-subunit in epididymis and brain. The different isoenzyme patterns and specific activities in mouse tissues are due to the differences in the amount of hexosaminidase subunits. The mRNA, evaluated by Northern blotting analyses, revealed a greater expression of alpha-subunit in the testis and of beta-subunit in the brain and epididymis. The results indicate, therefore, that gene expression and the amount of subunits are in goodrelationship for beta-subunit, whereas there is no correlation for alpha-subunit. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 10:00:22