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Titolo:
STABILITY OF LABETALOL HYDROCHLORIDE WITH SELECTED CRITICAL CARE DRUGS DURING SIMULATED Y-SITE INJECTION
Autore:
HASSAN E; LESLIE J; MARTIRHERRERO ML;
Indirizzi:
UNIV MARYLAND,SCH PHARM,100 PENN ST,SUITE 205-C BALTIMORE MD 21211 WASHINGTON HOSP CTR,DEPT PHARM SERV WASHINGTON DC 20010
Titolo Testata:
American journal of hospital pharmacy
fascicolo: 17, volume: 51, anno: 1994,
pagine: 2143 - 2145
SICI:
0002-9289(1994)51:17<2143:SOLHWS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPATIBILITY;
Keywords:
ADDITIVES; DOBUTAMINE HYDROCHLORIDE; DOPAMINE HYDROCHLORIDE; GASTROINTESTINAL DRUGS; HYPOTENSIVE AGENTS; INCOMPATIBILITIES; INJECTIONS; LABETALOL HYDROCHLORIDE; MORPHINE SULFATE; NITROGLYCERIN; OPIATES; RANITIDINE HYDROCHLORIDE; STABILITY; STORAGE; SYMPATHOMIMETIC AGENTS; VASODILATING AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
E. Hassan et al., "STABILITY OF LABETALOL HYDROCHLORIDE WITH SELECTED CRITICAL CARE DRUGS DURING SIMULATED Y-SITE INJECTION", American journal of hospital pharmacy, 51(17), 1994, pp. 2143-2145

Abstract

The compatibility and stability of labetalol hydrochloride in combination with various critical care drugs was evaluated. Labetalol hydrochloride 1.0 mg/mL was combined in 5% dextrose injection with equal volumes of each of the following drugs: dobutamine 2.5 mg/mL (as the hydrochloride salt), dopamine hydrochloride 1.6 mg/mL, morphine sulfate 0.5mg/mL, nitroglycerin 0.2 mg/mL, and ranitidine 0.6 mg/mL (as the hydrochloride salt). The mixtures were placed in duplicate Y-site administration sets. Visual inspection, pH determination, and high-performanceliquid chromatography were performed in duplicate on samples removed at zero, two, and four hours. No change in pH or appearance occurred throughout the study. All drug concentrations remained above 90% of theinitial concentration in each combination. Labetalol hydrochloride 1.0 mg/mL and dobutamine 2.5 mg/mL (as the hydrochloride salt), dopaminehydrochloride 1.6 mg/mL, morphine sulfate 0.5 mg/mL, nitroglycerin 0.2 mg/mL, or ranitidine 0.6 mg/mL (as the hydrochloride salt) in 5% dextrose injection were stable and compatible for up to four hours at 20-25 degrees C during simulated Y-site injection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:53:17