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Titolo:
LOW DOPAMINE TRANSPORTER MESSENGER-RNA LEVELS IN MIDBRAIN REGIONS CONTAINING CALBINDIN
Autore:
SANGHERA MK; MANAYE KF; LIANG CL; IACOPINO AM; BANNON MJ; GERMAN DC;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT DALLAS TX 75235 BAYLOR COLL DENT,DEPT BIOMED SCI DALLAS TX 75246 WAYNE STATE UNIV,DEPT PSYCHIAT DETROIT MI 48235
Titolo Testata:
NeuroReport
fascicolo: 13, volume: 5, anno: 1994,
pagine: 1641 - 1644
SICI:
0959-4965(1994)5:13<1641:LDTMLI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED PARKINSONISM; MESSENGER-RNA; NEURONS; EXPRESSION; DISEASE; MONKEYS; CELLS; RAT;
Keywords:
MIDBRAIN DOPAMINERGIC (DA) NEURONS; HUMAN DOPAMINE TRANSPORTER (DAT); CALBINDIN-D-28K (CALB); IN SITU HYBRIDIZATION; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Sanghera et al., "LOW DOPAMINE TRANSPORTER MESSENGER-RNA LEVELS IN MIDBRAIN REGIONS CONTAINING CALBINDIN", NeuroReport, 5(13), 1994, pp. 1641-1644

Abstract

THE dopamine transporter (DAT) is the site at which the neurotoxic metabolite of MPTP gains access to midbrain dopaminergic (DA) neurons. However, not all midbrain DA neurons degenerate following MPTP treatment. The midbrain DA neurons that contain the calcium-binding protein, calbindin-D-28k (CALB), are relatively invulnerable to MPTP toxicity, compared with DA neurons that lack CALB. Using in situ hybridization and immunocytochemical staining techniques in the rat and mouse, we now report that there is as much as 10 fold less DAT mRNA in regions whereDA neurons contain CALB compared with regions where DA neurons lack CALB. These data suggest that specific midbrain DA neurons are invulnerable to MPTP toxicity not only because they contain CALB, but also because they have relatively low DAT activity.

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Documento generato il 11/07/20 alle ore 07:24:13