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Titolo:
UNDERSTANDING THE SODIUM-PUMP AND ITS RELEVANCE TO DISEASE
Autore:
ROSE AM; VALDES R;
Indirizzi:
UNIV LOUISVILLE,SCH MED,DEPT PATHOL LOUISVILLE KY 40292 UNIV LOUISVILLE,SCH MED,DEPT PATHOL LOUISVILLE KY 40292 UNIV LOUISVILLE,SCH MED,DEPT BIOCHEM LOUISVILLE KY 40292
Titolo Testata:
Clinical chemistry
fascicolo: 9, volume: 40, anno: 1994,
pagine: 1674 - 1685
SICI:
0009-9147(1994)40:9<1674:UTSAIR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIGITALIS-LIKE-FACTOR; TISSUE-SPECIFIC EXPRESSION; NA,K-ATPASE ALPHA-SUBUNIT; OUABAIN-LIKE COMPOUND; NA+-K+-ATPASE; DIGOXIN-LIKE IMMUNOREACTIVITY; VOLUME EXPANDED HYPERTENSION; INCREASED CIRCULATING LEVELS; RAT CARDIAC VENTRICLE; AMINO-ACID-SEQUENCE;
Keywords:
NA,K-ATPASE; ISOFORMS; CARDIAC GLYCOSIDES; AGE-RELATED EFFECTS; DIGOXIN; OUABAIN; HYPERTENSION; DIABETES; ALZHEIMER DISEASE; NEUROLOGICAL DISORDERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
149
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Rose e R. Valdes, "UNDERSTANDING THE SODIUM-PUMP AND ITS RELEVANCE TO DISEASE", Clinical chemistry, 40(9), 1994, pp. 1674-1685

Abstract

Na,K-ATPase (sodium pump; EC 3.6.1.37) is present in the membrane of most eukaryotic cells and controls directly or indirectly many essential cellular functions. Regulation of this enzyme (ion transporter) andits individual isoforms is believed to play a key role in the etiology of some pathological processes. The sodium pump is the only known receptor for the cardiac glycosides. However, endogenous ligands structurally similar to digoxin or ouabain may control the activity of this important molecular complex. Here we review the structure and function of Na,K-ATPase, its expression and distribution in tissues, and its interaction with known ligands such as the cardiac glycosides and other suspected endogenous regulators. Also reviewed are various disorders, including cardiovascular, neurological, renal, and metabolic diseases,purported to involve dysfunction of Na,K-ATPase activity. The escalation in knowledge at the molecular level concerning sodium pump function foreshadows application of this knowledge in the clinical laboratoryto identify individuals at risk for Na,K-ATPase-associated diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:40:39