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Titolo:
BINDING CONSTANT DETERMINATION OF WIN-22169, A NOVEL POLYMERIC LIGAND
Autore:
CHELLQUIST EM; SEARLE R; LADD DL; HOLLISTER RK;
Indirizzi:
STERLING WINTHROP,DIV PHARMACEUT RES,POB 5000 COLLEGEVILLE PA 19426
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 8, volume: 12, anno: 1994,
pagine: 1015 - 1022
SICI:
0731-7085(1994)12:8<1015:BCDOWA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX;
Keywords:
HPLC, POTENTIOMETRIC TITRATION; BINDING CONSTANT; FORMATION CONSTANT; STABILITY CONSTANT; GADOLINIUM; MRI CONTRAST AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Chellquist et al., "BINDING CONSTANT DETERMINATION OF WIN-22169, A NOVEL POLYMERIC LIGAND", Journal of pharmaceutical and biomedical analysis, 12(8), 1994, pp. 1015-1022

Abstract

WIN 22169 is a co-polymer containing approximately 11 repeating unitsof polyoxyethylene and diethylenetriamine pentaacetic acid (DTPA). WIN 66368, a magnetic resonance imaging (MRI) contrast agent, is the gadolinium III complex of WIN 22169. WIN 22169 has been characterized with respect to its equivalent weight, acidity constants and excess acid or base, as well as its metal ion binding constants. The logs of the equilibrium binding constants of the ligand to Gd3+, Ca2+, Zn2+ and Cu2 were found to be 16.6, 7.47, 12.2 and 14.0. The Gd selectivity constant, a measure of the preferential binding of the ligand toward Gd3+ versus the three in vivo ions: Ca2+, Zn2+ and Cu2+, of WIN 66368 was calculated to be 7.9. This value compares favourably to that for Gd DTPAwhich has a Gd selectivity constant of 7.04.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:17:49