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Titolo:
CLINICAL AND IMMUNOGENETIC EFFECTS OF PRE SEASONAL HYPOSENSITIZATION IN CHILDREN WITH POLLINOSIS
Autore:
ENG PA; GNEHM HE; JOLLERJEMELKA HI;
Indirizzi:
KANTONSSPITAL,KINDERKLIN CH-5001 AARAU SWITZERLAND
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 8, volume: 142, anno: 1994,
pagine: 616 - 622
SICI:
0026-9298(1994)142:8<616:CAIEOP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
GER
Keywords:
PRESEASONAL IMMUNOTHERAPY; HYPOSENSITIZATION; LOCAL AND SYSTEMIC EFFECTS; PRICK SKIN TEST; ALLERGEN SPECIFIC IGG SUBCLASS ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Eng et al., "CLINICAL AND IMMUNOGENETIC EFFECTS OF PRE SEASONAL HYPOSENSITIZATION IN CHILDREN WITH POLLINOSIS", Monatsschrift fur Kinderheilkunde, 142(8), 1994, pp. 616-622

Abstract

Background: Safety, clinical efficacy and immunogenic effect of preseasonal immunotherapy with a depot-allergoid extract ought to be documented in children with pollinosis before routine clinical use of this mode of hyposensitization can be recommended. Methods: 14 children withpollen allergy were prospectively treated with s.c. injections of a depot-allergoid-extract. We recorded 1. local and systemic reactions, 2.variations of symptoms and total drug requirements, 3. changes of skin reactions (Prick test) and 4. determinations of specific IgG-antibodies before and after two immunotherapies. The control group consisted of 14 pollen allergic children, who were only symptomatically treated over the same time period. Results: After a total of 321 s.c. injections there were no systemic reactions, local reactions however were recorded in 4,7%. Allergic symptoms and drug requirement were decreased after two courses of immunotherapy. A significant decrease in skin reactions to allergens (p<0,01) was observed in contrast to an increase in symptomatically treated children. Specific antibodies of all IgG-subclasses increased significantly after two immunotherapies. Conclusions: The preseasonal immunotherapy with depot-allergoid extract is safe andwell tolerated. Children with confirmed pollinosis complained of fewer and less severe symptoms. There was an immunogenic effect after a second treatment course.

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Documento generato il 27/11/20 alle ore 13:27:55