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Titolo:
THERAPEUTIC AND PROTECTIVE EFFECT OF SUBCUTANEOUS INJECTIONS OF L-364,718 ON CERULEIN-INDUCED ACUTE-PANCREATITIS
Autore:
GARCIAMONTERO AC; MANSO MA; RODRIGUEZ AI; DEDIOS I;
Indirizzi:
UNIV SALAMANCA,FAC BIOL,DEPT PHYSIOL & PHARMACOL,EDIFICIO DEPT E-37007 SALAMANCA SPAIN UNIV SALAMANCA,FAC BIOL,DEPT PHYSIOL & PHARMACOL,EDIFICIO DEPT E-37007 SALAMANCA SPAIN
Titolo Testata:
Pancreas
fascicolo: 3, volume: 9, anno: 1994,
pagine: 309 - 315
SICI:
0885-3177(1994)9:3<309:TAPEOS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ RECEPTOR ANTAGONIST; CERULEIN-INDUCED PANCREATITIS; CCK-ANTAGONIST; RAT; SECRETION; STIMULATION; SECRETAGOGUE; MEMBRANE; L364718; AMYLASE;
Keywords:
ACUTE PANCREATITIS; CERULEIN; L-364,718; PANCREAS-RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A.C. Garciamontero et al., "THERAPEUTIC AND PROTECTIVE EFFECT OF SUBCUTANEOUS INJECTIONS OF L-364,718 ON CERULEIN-INDUCED ACUTE-PANCREATITIS", Pancreas, 9(3), 1994, pp. 309-315

Abstract

The prophylactic and therapeutic effects of a potent cholecystokinin (CCK) receptor antagonist, L-364,718, on acute pancreatitis induced bycaerulein were evaluated, analyzing morphologic and functional pancreatic parameters jointly. Edematous pancreatitis was induced by four subcutaneous injections of caerulein (20 mug/kg) in rats at 1-h intervals. Prophylactic administration of L-364,718 (0.1 mg/kg) prevented risein serum amylase levels, interstitial edema, vacuolization, and impairment of pancreatic enzyme secretion that accompany caerulein-induced acute pancreatitis. After 7 days, a spontaneous regression of the morphologic alterations caused by caerulein-induced acute pancreatitis occurs; however, recovery of the secretory function of the pancreas was only reached after this period of time when L-364,718 was administered therapeutically (0.1 mg/kg/day). Prophylactically or therapeutically administered, L-364,718 exerts a beneficial effect on caerulein-inducedacute pancreatitis, indicating that CCK (exogenous or endogenous) plays an important role in the development of this pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:42:00