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Titolo:
GENE-THERAPY FOR HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION - GENETIC ANTIVIRAL STRATEGIES AND TARGETS FOR INTERVENTION
Autore:
DROPULIC B; JEANG KT;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,CTR ONCOL,418 N BOND ST BALTIMORE MD 21231 NIAID,MOLEC MICROBIOL LAB,MOLEC VIROL SECT BETHESDA MD 20892
Titolo Testata:
Human gene therapy
fascicolo: 8, volume: 5, anno: 1994,
pagine: 927 - 939
SICI:
1043-0342(1994)5:8<927:GFHI-G>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEAT; RECOMBINANT SOLUBLE CD4; INHIBITS HIV-1 REPLICATION; HEMATOPOIETIC STEM-CELLS; AIDS-RELATED COMPLEX; RNA-BINDING PROTEIN; WILD-TYPE VIRUS; T-CELL; RETROVIRAL VECTORS; ANTISENSE OLIGODEOXYNUCLEOTIDES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
128
Recensione:
Indirizzi per estratti:
Citazione:
B. Dropulic e K.T. Jeang, "GENE-THERAPY FOR HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION - GENETIC ANTIVIRAL STRATEGIES AND TARGETS FOR INTERVENTION", Human gene therapy, 5(8), 1994, pp. 927-939

Abstract

Gene therapeutic strategies for the treatment of human immunodeficiency virus type 1 (HIV-1) infection have received increased attention due to lack of chemotherapeutic drugs of vaccines that show long-term efficacy in vivo. An emerging group, referred to here as ''genetic antivirals,'' is reviewed. Genetic antivirals are defined as DNA or RNA elements that are transferred into cells and affect their intracellular targets either directly, or after expression as RNA or proteins. They include antisense oligonucleotides, ribozymes, RNA decoys, transdominant mutants, toxins, and immunogens. They offer the possibility to target simultaneously multiple sites in the HIV genome, thereby minimizing the production of resistant viruses. We review the molecular mechanisms of genetic antivirals, their HIV molecular targets, and discuss issues concerning their application as anti-HIV agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:40:05