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Titolo:
THE EFFECT OF CHLORTHALIDONE ON VENTRICULAR ECTOPIC ACTIVITY IN PATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION
Autore:
KOSTIS JB; LACY CR; HALL WD; WILSON AC; BORHANI NO; KRIEGER SD; COSGROVE NM;
Indirizzi:
UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT MED,1 ROBERT WOOD JOHNSON PL,CN 19 NEW BRUNSWICK NJ 08903
Titolo Testata:
The American journal of cardiology
fascicolo: 5, volume: 74, anno: 1994,
pagine: 464 - 467
SICI:
0002-9149(1994)74:5<464:TEOCOV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIURETIC-INDUCED HYPOKALEMIA; UNCOMPLICATED SYSTEMIC HYPERTENSION; CARDIAC-ARRHYTHMIAS; PROGNOSTIC-SIGNIFICANCE; MYOCARDIAL-INFARCTION; THIAZIDE TREATMENT; SERUM POTASSIUM; THERAPY; HYPERTROPHY; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Kostis et al., "THE EFFECT OF CHLORTHALIDONE ON VENTRICULAR ECTOPIC ACTIVITY IN PATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION", The American journal of cardiology, 74(5), 1994, pp. 464-467

Abstract

In an ancillary study of the Systolic Hypertension in the Elderly Program (SHEP), the effects of diuretics on ventricular ectopic activity were investigated in 186 patients with isolated systolic hypertension. Ventricular premature complexes (VPCs) were examined as the number ofVPCs/24 hours, presence of greater than or equal to 1 VPC, presence of greater than or equal to 10 VPCs/24 hours, and presence of VPC pairsor ventricular tachycardia. Significant changes in VPCs were not observed either in the 92 patients randomized to chlorthalidone stepped-care (12.5 and 25 mg/day) or in the 94 placebo-treated patients (p >0.1 for all VPC definitions and both groups). Serum potassium decreased from 4.4 +/- 0.5 to 4.1 +/- 0.5 mEq/liter (P = 0.002) in the chlorthalidone group and did not change (4.4 +/- 0.5 to 4.5 +/- 0.4 mEq/liter) inthe placebo group. Potassium was prescribed routinely for confirmed hypokalemia <3.5 mEq/liter. A relation between serum potassium and VPC or change in serum potassium and change in VPG was not observed in thechlorthalidone group. In summary, in patients with isolated systolic hypertension, chlorthalidone in doses that are effective in decreasingstroke and cardiovascular event rates (12.5 or 25 mg/day), did not increase VPCs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:04:04