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Titolo:
EFFLUX MECHANISMS OF RESISTANCE TO CADMIUM, ARSENIC AND ANTIMONY IN PROKARYOTES AND EUKARYOTES
Autore:
TSAI KJ; HSU CM; ROSEN BP;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DEPT BIOCHEM & MOL BIOL DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT BIOCHEM & MOL BIOL DETROIT MI 48201 CHUNG SHAN MED & DENT COLL,SCH MED TECHNOL TAICHUNG 40227 TAIWAN NATL SUN YAT SEN UNIV,DEPT BIOL KAOHSIUNG 804 TAIWAN
Titolo Testata:
Zoological studies
fascicolo: 1, volume: 36, anno: 1997,
pagine: 1 - 16
SICI:
1021-5506(1997)36:1<1:EMORTC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANION-TRANSLOCATING ATPASE; PLASMID-DETERMINED RESISTANCE; AMINO-ACID-SEQUENCE; STAPHYLOCOCCUS-AUREUS PLASMID-PI258; MUSCLE SARCOPLASMIC-RETICULUM; EVERTED MEMBRANE-VESICLES; ACTING REGULATORY PROTEIN; NUCLEOTIDE-BINDING SITE; CALCIUM-PUMP PROTEIN; S-TRANSFERASE-PI;
Keywords:
EFFLUX; RESISTANCE; CADMIUM; ARSENIC; ANTIMONY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
118
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Tsai et al., "EFFLUX MECHANISMS OF RESISTANCE TO CADMIUM, ARSENIC AND ANTIMONY IN PROKARYOTES AND EUKARYOTES", Zoological studies, 36(1), 1997, pp. 1-16

Abstract

Resistance to toxic metals is ubiquitously found in prokaryotes, bothgram positive and gram negative, and in all types of eukaryotes, including fungi, plants, protozoans, and animals. In both prokaryotes and eukaryotes, toxic metals are extruded from cells through afflux transport systems to confer this resistance. Although the chemical substrates recognized by each transport system vary considerably, many heavy metal and metalloid translocating ATPases have been identified by evolutionarily unrelated pumps that have evolved the same function. Among these efflux mechanisms of resistance to heavy metals and metalloids, bacterial cadmium resistance is mediated by a primary transporter while the thiol-linked efflux systems have developed for cadmium resistance in eukaryotes. In contrast, bacterial resistance to arsenicals and antimonials is mediated by a primary ATP-coupled pump in association witha catalytic subunit, whereas an ATP-coupled As-thiol pump has evolvedto confer the resistance in eukaryotic systems. The biochemical aspects of the efflux mechanisms related to cadmium, arsenic, and antimony resistance in prokaryotes and eukaryotes are discussed in detail in the present review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:03:16