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Titolo:
BIOCHEMICAL MODULATION OF INTRAPERITONEAL FLUOROURACIL BY ALLOPURINOL- THE EFFECT ON AN EXPERIMENTAL ADENOCARCINOMA IN THE LIVER
Autore:
LINDNER P; CARLSSON G; GUSTAVSSON B; HOLMBERG SB; NAREDI P; PETERSON A; HAFSTROM L;
Indirizzi:
GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT SURG S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT SURG S-41345 GOTHENBURG SWEDEN OSTRA HOSP,DEPT SURG S-41685 GOTHENBURG SWEDEN CELLTOX AB S-42132 VASTRA FROLUNDA SWEDEN
Titolo Testata:
Anticancer research
fascicolo: 3A, volume: 14, anno: 1994,
pagine: 847 - 852
SICI:
0250-7005(1994)14:3A<847:BMOIFB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC-ARTERY LIGATION; TUMOR GROWTH; 5-FLUOROURACIL; TOXICITY; RATS; CANCER;
Keywords:
5-FU; ALLOPURINOL; LIVER TUMORS; INTRAPERITONEAL ADMINISTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
P. Lindner et al., "BIOCHEMICAL MODULATION OF INTRAPERITONEAL FLUOROURACIL BY ALLOPURINOL- THE EFFECT ON AN EXPERIMENTAL ADENOCARCINOMA IN THE LIVER", Anticancer research, 14(3A), 1994, pp. 847-852

Abstract

In a rat liver tumour system with a nitrosoguanidine-induced carcinoma and in an in vitro system with the same tumour, the effect of allopurinol on the toxicity and antitumour effect of 5-fluorouracil (5-FU) was explored. Two doses of 5-FU, 30 and 60 mg/kg b.w. intraperitoneally(i.p.), were tested with a large dose of allopurinol subcutaneously (s.c. ) (300 mg) in rats. The drugs were given for three consecutive days. The lethal toxicity of 60 mg 5-FU i.p. could not be counteracted byallopurinol. Allopurinol nd 30 mg 5-FU reduced the tumour growth ratemore than 5-FU alone. The spleen was smaller, as a sign of increased toxicity, without allopurinol. The concentration of allopurinol and its metabolites in the general circulation was high. In vitro, there wasno additive or specific effect of allopurinol. These results indicatesome in vivo metabolic modulation of 5-FU efficacy by allopurinol if 5-FU is administered intraperitoneally and allopurinol systemically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:03:42