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Titolo:
THE CAMP-DEPENDENT PROTEIN-KINASES AND CAMP SIGNAL-TRANSDUCTION
Autore:
BEEBE SJ;
Indirizzi:
EASTERN VIRGINIA MED SCH,DEPT PHYSIOL,POB 1980,700 OLNEY RD NORFOLK VA 23501 EASTERN VIRGINIA MED SCH,DEPT PEDIAT NORFOLK VA 23501
Titolo Testata:
Seminars in cancer biology
fascicolo: 4, volume: 5, anno: 1994,
pagine: 285 - 294
SICI:
1044-579X(1994)5:4<285:TCPACS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
3',5'-CYCLIC ADENOSINE-MONOPHOSPHATE; TISSUE-SPECIFIC EXTINGUISHER; CATALYTIC SUBUNIT; CYCLIC-AMP; REGULATORY SUBUNIT; CELL-LINE; C-GAMMA; BINDING DOMAINS; TSE1 ENCODES; TUMOR-CELLS;
Keywords:
CAMP SIGNALING; PROTEIN KINASE A ISOFORMS; PHOSPHORYLATION; MOLECULAR GENETIC; MUTANTS; MICROINJECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Beebe, "THE CAMP-DEPENDENT PROTEIN-KINASES AND CAMP SIGNAL-TRANSDUCTION", Seminars in cancer biology, 5(4), 1994, pp. 285-294

Abstract

The cAMP signal transduction system is one of several second messenger-dependent pathways that generates intracellular responses to extracellular signals. The primary element in this cascade is the cAMP-dependent protein kinases(PKA), which mediate most cAMP actions by phosphorylation. Regulatory subunit isoforms bind cAMP and localize catalytic subunit isoforms near substrate proteins. C-subunit isoforms also may have specific roles in PKA function. Compared to the C alpha-subunit isoform, C gamma has a more limited distribution, a different substrate and inhibitor specificity, and appears to require higher levels of cAMP for activation. Many PKA isoforms with differing localization, regulatory, and kinetic properties are thus possible The potential roles for R- and C-subunits are discussed in the broad context of cAMP/PKA-mediated cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:31:35