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Titolo:
DOPAMINE D-2 AND D-3 RECEPTORS INHIBIT DOPAMINE RELEASE
Autore:
TANG L; TODD RD; OMALLEY KL;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 270, anno: 1994,
pagine: 475 - 479
SICI:
0022-3565(1994)270:2<475:DDADRI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC-AMP ACCUMULATION; RAT CORPUS STRIATUM; D2 DOPAMINE; ADENYLATE-CYCLASE; POTASSIUM CONDUCTANCE; MESSENGER-RNA; G-PROTEINS; NEURONS; CLONING; K+;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L. Tang et al., "DOPAMINE D-2 AND D-3 RECEPTORS INHIBIT DOPAMINE RELEASE", The Journal of pharmacology and experimental therapeutics, 270(2), 1994, pp. 475-479

Abstract

D-2-like dopamine receptors are thought to control presynaptic dopamine synthesis and release. Because these receptors comprise a family which includes D-2, D-3 and D-4 dopamine receptors, the question arises as to which subtype performs what role(s). To investigate the potential autoreceptor roles of these proteins, D-2, D-3 and D-4 receptors were transfected into a mesencephalic clonal cell line which synthesizes and releases dopamine. Here we report that stimulation of transfected D-2 and D-3 receptors, but not D-4 receptors, inhibits dopamine release from this dopaminergic cell line. This is the first report of a functional role for D-3 receptors and establishes these cell lines as a convenient in vitro model system to study signal transduction mechanismsassociated with autoreceptor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:26:07