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Titolo:
LOSS OF APC AND THE ENTIRE CHROMOSOME-18 BUT ABSENCE OF MUTATIONS AT THE RAS AND TP53 GENES IN INTESTINAL TUMORS FROM APC1638N, A MOUSE MODEL FOR APC-DRIVEN CARCINOGENESIS
Autore:
SMITS R; KARTHEUSER A; JAGMOHANCHANGUR S; LEBLANC V; BREUKEL C; DEVRIES A; VANKRANEN H; VANKRIEKEN JH; WILLIAMSON S; EDELMANN W; KUCHERLAPATI R; KAN PM; FODDE R;
Indirizzi:
LEIDEN STATE UNIV,DEPT HUMAN GENET,SYLVIUS LAB,MGC,WASSENAARSEWEG 72 NL-2333 AL LEIDEN NETHERLANDS LEIDEN STATE UNIV,DEPT HUMAN GENET,SYLVIUS LAB,MGC NL-2333 AL LEIDEN NETHERLANDS UNIV LOUVAIN,DEPT SURG BRUSSELS BELGIUM RIVM,LAB CARCINOGENESIS & MUTAGENESIS BILTHOVEN NETHERLANDS LEIDEN UNIV,DEPT PATHOL NL-2300 RA LEIDEN NETHERLANDS UNIV NEWCASTLE UPON TYNE,ROYAL VICTORIA INFIRM,DEPT PATHOL NEWCASTLE TYNE NE1 4LP TYNE & WEAR ENGLAND YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOL GENET NEW YORK NY 00000
Titolo Testata:
Carcinogenesis
fascicolo: 2, volume: 18, anno: 1997,
pagine: 321 - 327
SICI:
0143-3334(1997)18:2<321:LOAATE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; COLI GENE; COLORECTAL TUMORIGENESIS; ALPHA-CATENIN; NEOPLASIA; MICE; CANCER; MAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
R. Smits et al., "LOSS OF APC AND THE ENTIRE CHROMOSOME-18 BUT ABSENCE OF MUTATIONS AT THE RAS AND TP53 GENES IN INTESTINAL TUMORS FROM APC1638N, A MOUSE MODEL FOR APC-DRIVEN CARCINOGENESIS", Carcinogenesis, 18(2), 1997, pp. 321-327

Abstract

The Apc1638N mouse carries a targeted mutant allele at the endogenousadenomatous polyposis coli (Ape) gene and represents a unique in vivomodel to study intestinal tumor formation and progression. Heterozygous Apc(+)/Apc1638N mice progressively develop 5-6 adenomas and adenocarcinomas of the small intestine within the first 6 months of life following a histologic sequence similar to that observed in human intestinal tumors, Here, we present the somatic mutation analysis of a total of 57 tumors, The results indicate that in greater than or equal to 75%of the lesions tested the wild type copy of the Ape gene is lost and that this LOH event extends to the entire mouse chromosome 18, Unexpectedly, mutations at the K-, N- and H-ras genes have not been found in these tumors. Immunohistochemical analysis of the Apc1638N tumors failed to detect accumulation of the Tp53 protein, Also, no mutations havebeen found in exons 7 and 8 of the Tp53 gene. These results indicate that, although the genetic inactivation of Ape is involved in the initiating event of the human as well as murine intestinal tumorigenesis, tumor growth and progression follow different mutational pathways in these two species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:39:15