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Titolo:
EFFECTS OF HYPOGLYCEMIA AND HYPERGLYCEMIA ON BRAIN ENERGY METABOLITESIN MICE EXPOSED TO CARBON-MONOXIDE
Autore:
MATSUOKA M; IGISU H; TANAKA I; HORI H; KOGA M;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM TOXICOL,YAHATANISHI KU KITAKYUSHU 807 FUKUOKA JAPAN UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM TOXICOL,YAHATANISHI KU KITAKYUSHU 807 FUKUOKA JAPAN UNIV OCCUPAT & ENVIRONM HLTH,COMMON USE RES CTR,YAHATANISHI KU KITAKYUSHU 807 FUKUOKA JAPAN UNIV OCCUPAT & ENVIRONM HLTH,DEPT ENVIRONM HLTH ENGN,YAHATANISHI KU KITAKYUSHU 807 FUKUOKA JAPAN
Titolo Testata:
Toxicology letters
fascicolo: 2, volume: 73, anno: 1994,
pagine: 135 - 143
SICI:
0378-4274(1994)73:2<135:EOHAHO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ISCHEMIA; BLOOD-GLUCOSE; RAT-BRAIN; HYPOGLYCEMIA; MORTALITY; RECOVERY; LACTATE; MODEL;
Keywords:
CARBON MONOXIDE; BLOOD GLUCOSE; BRAIN ENERGY METABOLISM; NEUROTOXICITY; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Matsuoka et al., "EFFECTS OF HYPOGLYCEMIA AND HYPERGLYCEMIA ON BRAIN ENERGY METABOLITESIN MICE EXPOSED TO CARBON-MONOXIDE", Toxicology letters, 73(2), 1994, pp. 135-143

Abstract

Hypoglycemia and hyperglycemia were induced in mice by fasting and byinjecting with glucose, respectively. These and normally fed (normoglycemic) animals were exposed to 0.5% carbon monoxide (CO) for 10 min. This altered concentrations of energy metabolites in the brain, including decreases in phosphocreatine (PCr) and increases in creatine and lactate. The only difference between normoglycemic and hypoglycemic mice was lower lactate in the latter. In hyperglycemic mice, PCr and ATP were better preserved during CO exposure and lactate was lower than innormoglycemic mice. Blood glucose concentrations correlated well withglucose but not with lactate in the brain. Thus, moderate hypo- or hyperglycemia seems not to exacerbate CO-induced alterations of brain energy metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:33:42