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Titolo:
THYROID-HORMONE RECEPTOR MESSENGER-RIBONUCLEIC-ACID IN HUMAN GRANULOSA AND OVARIAN STROMAL CELLS
Autore:
WAKIM AN; PALJUG WR; JASNOSZ KM; ALHAKIM N; BROWN AB; BURHOLT DR;
Indirizzi:
ALLEGHENY GEN HOSP,DEPT OBSTET & GYNECOL,320 E NORTH AVE PITTSBURGH PA 15212 MED COLL PENN,DEPT OBSTET & GYNECOL PITTSBURGH PA 00000
Titolo Testata:
Fertility and sterility
fascicolo: 3, volume: 62, anno: 1994,
pagine: 531 - 534
SICI:
0015-0282(1994)62:3<531:TRMIHG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Keywords:
THYROID HORMONE RECEPTOR MESSENGER-RNA; HUMAN GRANULOSA CELLS; OVARIAN STOMAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A.N. Wakim et al., "THYROID-HORMONE RECEPTOR MESSENGER-RIBONUCLEIC-ACID IN HUMAN GRANULOSA AND OVARIAN STROMAL CELLS", Fertility and sterility, 62(3), 1994, pp. 531-534

Abstract

Objective: To examine whether mRNA for thyroid hormone receptors alpha and beta is present in human granulosa cells in nonstimulated ovaries. Design: Paraffin-embedded sections of ovaries from normally cyclingwomen were analyzed by in situ hybridization with oligonucleotide probes for thyroid hormone receptors alpha and beta. The sense strand oligonucleotide was used as a control for each of the probes. Results: Granulosa cells from the preovulatory antral follicles examined showed positive staining for both the thyroid hormone receptor alpha and beta probes. Positive staining of ovarian stromal cells also was observed for both probes. Conclusion: Thyroid hormone receptor mRNAs are expressed in both granulosa cells and ovarian stromal cells found in nonstimulated ovaries. It is, therefore, conceivable that thyroid hormone may play a direct role in human ovarian physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:38:51