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Titolo:
PROGNOSTIC-SIGNIFICANCE AND SURGICAL-MANAGEMENT OF LOCOREGIONAL LYMPH-NODE METASTASES IN PAPILLARY THYROID-CANCER
Autore:
SCHEUMANN GFW; GIMM O; WEGENER G; HUNDESHAGEN H; DRALLE H;
Indirizzi:
HANNOVER MED SCH,ABDOMINAL & TRANSPLANTAT CHIRURG KLIN,KONSTANTY GUTSCHOW STR 8 D-30625 HANNOVER GERMANY HANNOVER MED SCH,KLIN KREBREGISTER NIEDERSACHSEN D-30625 HANNOVER GERMANY HANNOVER MED SCH,NUKL MED & SPEZIELLE BIOPHYS KLIN D-30625 HANNOVER GERMANY
Titolo Testata:
World journal of surgery
fascicolo: 4, volume: 18, anno: 1994,
pagine: 559 - 568
SICI:
0364-2313(1994)18:4<559:PASOLL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECK DISSECTION; CARCINOMA; SURVIVAL; THERAPY; CHILDREN; IMPACT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
G.F.W. Scheumann et al., "PROGNOSTIC-SIGNIFICANCE AND SURGICAL-MANAGEMENT OF LOCOREGIONAL LYMPH-NODE METASTASES IN PAPILLARY THYROID-CANCER", World journal of surgery, 18(4), 1994, pp. 559-568

Abstract

We studied the records of 342 patients with papillary thyroid carcinoma out of a total of 728 thyroid cancer patients treated at the Medical School of Hannover (MHH) from 1972 through 1992. The comprehensive data abstracting forms were designed, and the acquired information was coded, stored, maintained, and evaluated by the Clinical Cancer Registry of the MHH. A total of 160 patients (46.8%) initially had lymph node metastases (N1 status). The N status significantly influenced recurrence (p < 0.00001) and survival (p < 0.00001). Excluding other risk factors developed by univariate and multivariate analysis, such as high age (age > 45 years, p < 0.001), tumor invasion (T4 tumor, p < 0.005),and distant metastases (Mi, p < 0.001), lymph node metastases remained an independent, highly significant prognostic marker for more aggressive papillary thyroid cancer. N1 status did not influence survival ofpatients with T4 tumor but did influence those with T1-T3 status (p <0.001). The influence of N1 status remained significant in patients older (p < 0.001) and younger (p < 0.05) than 45 years of age. Systematic compartment-oriented dissection of lymph node metastases improved survival (p < 0.005, T1-T3) and recurrence (p < 0.00001, T1-T3) especially in patients with T1-T3 tumors. In conclusion, lymph node metastases with a significant incidence at a young age and male sex had a substantial effect on survival and recurrence especially in those with tumor status T1-T3. Systematic compartment-oriented dissection of the lymph node metastases results in better survival and a lower recurrence rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:11:51