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Titolo:
DIFFERENT PATTERNS OF [F-18] DOPA UPTAKE IN SIBLINGS WITH HEREDITARY DENTATO-RUBRO-PALLIDO-LUYSIAN ATROPHY
Autore:
MINAMI T; OTSUKA M; ICHIYA Y; NOMURA A; UEDA K;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT PEDIAT,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812JAPAN KYUSHU UNIV,FAC MED,DEPT RADIOL FUKUOKA JAPAN
Titolo Testata:
Brain & development
fascicolo: 4, volume: 16, anno: 1994,
pagine: 335 - 338
SICI:
0387-7604(1994)16:4<335:DPO[DU>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 DOPA UPTAKE; PARKINSONS-DISEASE; GLUCOSE;
Keywords:
HEREDITARY DENTATO-RUBRO-PALLIDO-LUYSIAN ATROPHY (HDRPLA); POSITRON EMISSION TOMOGRAPHY (PET); [F-18] DOPA; [F-18] FDG;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Minami et al., "DIFFERENT PATTERNS OF [F-18] DOPA UPTAKE IN SIBLINGS WITH HEREDITARY DENTATO-RUBRO-PALLIDO-LUYSIAN ATROPHY", Brain & development, 16(4), 1994, pp. 335-338

Abstract

Striatal glucose metabolism and [F-18]dopa uptake were studied by positron emission tomography (PET) in two siblings with hereditary dentato-rubro-pallido-luysian atrophy (HDRPLA). The regional cerebral metabolic rate of glucose showed marked decreases in the cerebellum and brainstem in both cases. The elder brother, who had trunk titubation and intention tremor of extremities, showed decreased [F-18]dopa uptake in the striatum. On the other hand, the younger brother, who had spontaneous myoclonus of the right shoulder and flank, showed increased [F-18]dopa uptake in the striatum. These findings suggested that the wide variety of clinical symptoms of HDRPLA observed within a single family is closely related to the various neuronal dysfunctions at the neurotransmitter level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:17:12