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Titolo:
AMINOPHYLLINE EXHIBITS CONVULSANT ACTION IN RATS DURING ONTOGENY
Autore:
MARES P; KUBOVA H; CZUCZWAR SJ;
Indirizzi:
ACAD SCI CZECH REPUBL,INST PHYSIOL,VIDENSKA 1083 CR-14220 PRAGUE 4 CZECH REPUBLIC CHARLES UNIV,DEPT PATHOPHYSIOL PRAGUE CZECH REPUBLIC CHARLES UNIV,DEPT PHARMACOL PRAGUE CZECH REPUBLIC CHARLES UNIV,FAC MED 3 PRAGUE CZECH REPUBLIC MARIE CURIE SKLODOWSKA UNIV,DEPT PHARMACOL LUBLIN POLAND
Titolo Testata:
Brain & development
fascicolo: 4, volume: 16, anno: 1994,
pagine: 296 - 300
SICI:
0387-7604(1994)16:4<296:AECAIR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
THEOPHYLLINE-INDUCED SEIZURES; BLOOD-BRAIN-BARRIER; ANTICONVULSANT ACTION; METRAZOL; MOTOR; INHIBITION; EPILEPSY; LESION; DRUGS; ACID;
Keywords:
DRUG-INDUCED SEIZURE; CONVULSANT DRUG; AMINOPHYLLINE; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P. Mares et al., "AMINOPHYLLINE EXHIBITS CONVULSANT ACTION IN RATS DURING ONTOGENY", Brain & development, 16(4), 1994, pp. 296-300

Abstract

Aminophylline-induced seizures were studied in 166 male albino rats in five age groups - 7, 12, 18, 25 and 90 days old. Aminophylline injected in doses from 150-350 mg/kg i.p. elicited both minimal, clonic andmajor, i.e. generalized tonic-clonic seizures during the 60-min observation period. The pattern of minimal seizures did not change during development; major seizures exhibited changes in proportion to their three phases - running, tonic and clonic phases. Dependence on the dose of aminophylline was observed in the incidence of major seizures as well as in shortening of latencies of both types of seizures. More marked convulsant effects of aminophylline in 7-, 12- and 18-day-old rat pups than in older animals might be due to pharmacokinetic as well as pharmacodynamic factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:09:46