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Titolo:
PLASMA-CONCENTRATIONS OF PROLACTIN, NORADRENALINE, VASOPRESSIN AND OXYTOCIN DURING AND AFTER A PROLONGED EPILEPTIC SEIZURE
Autore:
MEIERKORD H; SHORVON S; LIGHTMAN SL;
Indirizzi:
HUMBOLDT UNIV BERLIN,KLINIKUM CHARITE,NEUROL KLIN,SCHUMANNSTR 20-21 D-10117 BERLIN GERMANY UNIV LONDON,NATL HOSP,INST NEUROL,DEPT CLIN NEUROL LONDON ENGLAND BRISTOL ROYAL INFIRM & GEN HOSP,DEPT MED BRISTOL AVON ENGLAND
Titolo Testata:
Acta neurologica Scandinavica
fascicolo: 2, volume: 90, anno: 1994,
pagine: 73 - 77
SICI:
0001-6314(1994)90:2<73:POPNVA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM PROLACTIN; ELECTROCONVULSIVE-THERAPY; HORMONAL RESPONSES; MESSENGER-RNA; SECRETION; STRESS;
Keywords:
EPILEPTIC SEIZURE; HORMONAL CHANGES; PROLACTIN; VASOPRESSIN; OXYTOCIN; NORADRENALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Meierkord et al., "PLASMA-CONCENTRATIONS OF PROLACTIN, NORADRENALINE, VASOPRESSIN AND OXYTOCIN DURING AND AFTER A PROLONGED EPILEPTIC SEIZURE", Acta neurologica Scandinavica, 90(2), 1994, pp. 73-77

Abstract

The time course and extent of changes in plasma prolactin, noradrenaline, vasopressin and oxytocin levels is reported following serial observations of a prolonged epileptic seizure arising in the temporal lobe, recorded by video-EEG-telemetry, in which the epileptic activity evolved from a simple partial to complex partial to secondarily generalised attack. The prolactin levels were markedly elevated during the phase of the simple partial seizure, at a time when consciousness was preserved, when motor activity was minimal and when EEG activity was highly localised. The hormonal levels continued to rise during the subsequent seizure evolution, suggesting that the duration (or intensity) of the seizure is an important, perhaps the most important, factor determining the degree of prolactin release during limbic seizures. Indeed, the prolactin elevation in this case (26 times the baseline level) is higher than any previously recorded, reflecting the unusual duration and intensity of this seizure. We did not observe the phenomenon of ''exhaustion'' of prolactin release and levels peaked after 49 min, and were high for over 2 h after the onset of the seizure, and after the convulsion had ceased. The concentrations of vasopressin, oxytocin and noradrenaline remained low during the aura, but rapidly increased duringthe phase of generalisation. The oxytocin and noradrenaline levels peaked during the phase of generalised convulsion, but the vasopressin levels peaked well into the post ictal phase, and remained high for several hours. The differing patterns of hormone release are likely to berelated to the different anatomical sites of the hypothalamic perikarya, the relative importance of excitatory and inhibitory hypophysiotrophic agents in the release of anterior pituitary hormones and the localised release of neuromodulatory agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:01:47