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Titolo:
GLUCOSE ATTENUATES A MORPHINE-INDUCED DECREASE IN HIPPOCAMPAL ACETYLCHOLINE OUTPUT - AN IN-VIVO MICRODIALYSIS STUDY IN RATS
Autore:
RAGOZZINO ME; WENK GL; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903 UNIV ARIZONA,DIV NEURAL SYST TUCSON AZ 00000
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 655, anno: 1994,
pagine: 77 - 82
SICI:
0006-8993(1994)655:1-2<77:GAAMDI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCOPOLAMINE-INDUCED AMNESIA; SPONTANEOUS-ALTERNATION; MEMORY STORAGE; BETA-ENDORPHIN; ELDERLY HUMANS; MICE; BRAIN; INJECTIONS; ENHANCEMENT; TURNOVER;
Keywords:
GLUCOSE; MORPHINE; ACETYLCHOLINE; MICRODIALYSIS; HIPPOCAMPUS; MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Ragozzino et al., "GLUCOSE ATTENUATES A MORPHINE-INDUCED DECREASE IN HIPPOCAMPAL ACETYLCHOLINE OUTPUT - AN IN-VIVO MICRODIALYSIS STUDY IN RATS", Brain research, 655(1-2), 1994, pp. 77-82

Abstract

Systemic injections of morphine impair performance in memory tests. Glucose administration ameliorates memory deficits produced by morphinetreatment. The memory impairments induced by morphine may be related to opioid inhibition of acetylcholine release with reversal of this effect by glucose. The present experiment determined whether: (1) systemic morphine treatment decreases acetylcholine output in the hippocampal formation; and (2) systemic glucose administration attenuates the effect of morphine treatment. Employing microdialysis, samples were collected at 12-min intervals and assayed for acetylcholine using HPLC with electrochemical detection. Morphine (10 mg/kg)/saline injections resulted in an immediate decrease in acetylcholine output (20-35%) that was observed up to the third postinjection sample (36 min). Glucose (100 mg/kg) administered concurrently with morphine attenuated the reduction in acetylcholine output in the second and third samples. These findings suggest that glucose may attenuate morphine-induced memory impairments by reversing a decrease in acetylcholine output produced by morphine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:44:16