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Titolo:
INCIDENCE, RACIAL-DIFFERENCES, AND PROGNOSTIC-SIGNIFICANCE OF PROSTATE CARCINOMAS DIAGNOSED WITH OBSTRUCTIVE SYMPTOMS
Autore:
BRAWN PN; JOHNSON EH; SPEIGHTS VO; RIGGS M; KUHL D; ABEL PD; LIND M; BELL N;
Indirizzi:
UNIV MICHIGAN,VET ADM MED CTR,DEPT PATHOL ANN ARBOR MI 48105 TEXAS A&M UNIV,COLL MED,VET ADM MED CTR,DEPT PATHOL TEMPLE TX 76508 TEXAS A&M UNIV,COLL MED,VET ADM MED CTR,TUMOR REGISTRAR TEMPLE TX 76508 TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP & CLIN,COLL MED,DEPT PATHOL TEMPLE TX 76508 TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP & CLIN,COLL MED,DEPT BIOSTAT TEMPLE TX 76508 HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG LONDON ENGLAND KELSEY SEYBOLD CLIN,DEPT RES & EDUC HOUSTON TX 00000
Titolo Testata:
Cancer
fascicolo: 5, volume: 74, anno: 1994,
pagine: 1607 - 1611
SICI:
0008-543X(1994)74:5<1607:IRAPOP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN LEVELS; ADENOCARCINOMA;
Keywords:
PROSTATE CARCINOMA; URINARY OBSTRUCTION; STAGE OF PROSTATE CARCINOMA; GRADE OF PROSTATE CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
P.N. Brawn et al., "INCIDENCE, RACIAL-DIFFERENCES, AND PROGNOSTIC-SIGNIFICANCE OF PROSTATE CARCINOMAS DIAGNOSED WITH OBSTRUCTIVE SYMPTOMS", Cancer, 74(5), 1994, pp. 1607-1611

Abstract

Background. It is unknown how often prostate carcinomas are diagnosedas a result of urinary obstructive symptoms or whether prostate carcinomas diagnosed because of obstructive symptoms have a favorable or unfavorable prognosis. It is also unknown whether racial differences in obstructive symptoms could help explain why black men with prostate carcinoma are diagnosed with more advanced stages and grades of prostatecarcinoma than are white men with prostate carcinoma. Method. At a single Veterans Administration Medical Center, 478 consecutive cases of prostate carcinoma diagnosed between 1973 and 1985 were identified. The incidence of obstructive symptoms at diagnosis, racial differences in obstructive symptoms, and the survival of patients with and without obstructive symptoms, stratified by stage and grade, were determined. In addition, racial differences in the frequency of surgical intervention required to relieve the obstructive symptoms were determined. Results. All patients diagnosed with Stage A prostate carcinoma and most (82%) patients diagnosed with Stage C prostate carcinoma had obstructive symptoms. Those diagnosed with Stage B and Stage D prostate carcinomas had with similar frequencies (53% and 55%, respectively) of obstructive symptoms. Survival, stratified by stage and grade, was similar for men with and without obstructive symptoms. The incidences of obstructive symptoms and the frequency of surgical intervention to relieve the obstructive symptoms, stage for stage, were similar for white and black men. Conclusion. Survival, stratified by stage and grade, is not affected adversely by obstructive symptoms. Neither racial differences in the incidence of obstructive symptoms nor the frequency with which obstructive symptoms require surgical correction explain why black menwith CAP consistently are diagnosed more frequently with Stage D prostate carcinoma and less frequently with Stage A CAP than white men with CAP.

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Documento generato il 12/07/20 alle ore 11:54:36