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Titolo:
HPLC DETERMINATION OF ENANTIOMERIC PURITY OF PROTECTED AMINO-ACID DERIVATIVES USED IN PEPTIDE-SYNTHESIS
Autore:
SZOKAN G; HADFI S; KRIZSAN K; LIEMBECK A; KRECZ I; ALMAS M; SOMLAI C;
Indirizzi:
LORAND EOTVOS UNIV,DEPT ORGAN CHEM,POB 32 H-1518 BUDAPEST 112 HUNGARY SZENT GYORGYI ALBERT MED UNIV SZEGED,INST MED CHEM H-6720 SZEGED HUNGARY
Titolo Testata:
Journal of liquid chromatography
fascicolo: 13, volume: 17, anno: 1994,
pagine: 2759 - 2775
SICI:
0148-3919(1994)17:13<2759:HDOEPO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; CATALYTIC TRANSFER HYDROGENATION; PRE-COLUMN DERIVATIZATION; RAPID REMOVAL; RESOLUTION; SEPARATION; RACEMIZATION; REAGENT; PHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
G. Szokan et al., "HPLC DETERMINATION OF ENANTIOMERIC PURITY OF PROTECTED AMINO-ACID DERIVATIVES USED IN PEPTIDE-SYNTHESIS", Journal of liquid chromatography, 17(13), 1994, pp. 2759-2775

Abstract

An improved RP-HPLC method on ODS-Hypersil column with precolumn derivatization with Marfey's reagent were used to monitor racemization in N-, C- and/or side-chain protected amino acid derivatives by separation of a series of new diastereoisomeric Marfey's compounds. Chromatographic samples were obtained by partial deprotection of different starting materials. In a simple two-step procedure (deprotection and derivatization) the compounds of amino acids formed stable diastereomeric derivatives having facile resolutions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:12:29