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Titolo:
NUTRITIONALLY AND CHEMICALLY-INDUCED IMPAIRMENT OF SULFATE ACTIVATIONAND SULFATION OF XENOBIOTICS IN-VIVO
Autore:
GREGUS Z; OGURO T; KLAASSEN CD;
Indirizzi:
UNIV PECS,SCH MED,DEPT PHARMACOL H-7625 PECS HUNGARY UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT KANSAS CITY KS66160
Titolo Testata:
Chemico-biological interactions
fascicolo: 1-3, volume: 92, anno: 1994,
pagine: 169 - 177
SICI:
0009-2797(1994)92:1-3<169:NACIOS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETAMINOPHEN METABOLITES; INORGANIC SULFATE; URINARY-EXCRETION; RAT-KIDNEY; TRANSPORT; INVIVO; INVITRO; BILIARY; SULFUR; TUBULE;
Keywords:
ACETAMINOPHEN; MOLYBDATE; PAPS; 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE; SULFATE; SULFATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Z. Gregus et al., "NUTRITIONALLY AND CHEMICALLY-INDUCED IMPAIRMENT OF SULFATE ACTIVATIONAND SULFATION OF XENOBIOTICS IN-VIVO", Chemico-biological interactions, 92(1-3), 1994, pp. 169-177

Abstract

Sulfation requires 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as the sulfate donor. In the search for methods to inhibit sulfation reactions via impairment of PAPS synthesis, two experimental conditions havebeen tested in rats. A low-sulfur diet, which does not deplete hepatic glutathione, reduced inorganic sulfate but not PAPS levels in the liver and moderately decreased sulfation of acetaminophen. Administration of molybdate, which is an alternative substrate for intestinal and renal sulfate transport as well as for ATP-sulfurylase, depleted both sulfate and PAPS in liver and markedly inhibited sulfation of acetaminophen. Therefore, administration of molybdate may be used as an experimental tool to study the role of sulfation in the fate and effect of xenobiotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:18:15