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Titolo:
THE RPA (RECEPTOR POTENTIAL ABSENT) VISUAL MUTANT OF THE BLOWFLY (CALLIPHORA-ERYTHROCEPHALA) IS DEFICIENT IN PHOSPHOLIPASE-C IN THE EYE
Autore:
MCKAY RR; MILLER K; WECKSTROM M; TORKKELI P; JARVILEHTO MJ; SHORTRIDGE RD;
Indirizzi:
SUNY COLL BUFFALO,DEPT SCI BIOL BUFFALO NY 14260 SUNY COLL BUFFALO,DEPT SCI BIOL BUFFALO NY 14260 UNIV OULU,DEPT PHYSIOL SF-90570 OULU FINLAND UNIV ALBERTA,DEPT PHYSIOL EDMONTON T6G 2H7 AB CANADA UNIV OULU,DEPT ZOOL SF-90220 OULU FINLAND
Titolo Testata:
Journal of neurogenetics
fascicolo: 3, volume: 9, anno: 1994,
pagine: 177 - 187
SICI:
0167-7063(1994)9:3<177:TR(PAV>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROD OUTER SEGMENTS; DROSOPHILA-MELANOGASTER; INOSITOL TRISPHOSPHATE; NORPA GENE; PHOTOTRANSDUCTION; PHOTORECEPTORS; MAINTENANCE; TRANSDUCTION; EXPRESSION; MEMBRANE;
Keywords:
VISION; SIGNALING; PHOTOTRANSDUCTION; PHOSPHOLIPASE C; COMPOUND EYE; DROSOPHILA; NORPA; CALLIPHORA; RPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Mckay et al., "THE RPA (RECEPTOR POTENTIAL ABSENT) VISUAL MUTANT OF THE BLOWFLY (CALLIPHORA-ERYTHROCEPHALA) IS DEFICIENT IN PHOSPHOLIPASE-C IN THE EYE", Journal of neurogenetics, 9(3), 1994, pp. 177-187

Abstract

The rpa (receptor potential absent) mutation of the blowfly, Calliphora erythrocephala, reduces the light-evoked responses of photoreceptorcells and renders the fly blind. This phenotype is similar to the phenotype caused by norpA mutations in Drosophila which have been shown to occur within a gene encoding phospholipase C. In Western blots, norpA antiserum stains a protein in homogenates of wild-type Calliphora eye and head that is similar in molecular weight to the norpA protein. Very little staining of this protein is observed in similar homogenatesof rpa mutant. Moreover, norpA antiserum strongly stains retina in immunohistochemical assays of wild-type adult head, but not in rpa mutant. Furthermore, eyes of rpa mutant have a reduced amount of phospholipase C activity compared to eye of wild-type Calliphora. These data suggest that the rpa mutation occurs in a phospholipase C gene of the blowfly that is homologous to the norpA gene of Drosophila.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:17:50