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Titolo:
DOWN-REGULATION OF ACTIN GENES PRECEDES MICROFILAMENT NETWORK DISRUPTION AND ACTIN CLEAVAGE DURING P53-MEDIATED APOPTOSIS
Autore:
GUENAL I; RISLER Y; MIGNOTTE B;
Indirizzi:
CNRS,CTR GENET MOL,UPR 9061 F-91198 GIF SUR YVETTE FRANCE CNRS,CTR GENET MOL,UPR 9061 F-91198 GIF SUR YVETTE FRANCE UNIV VERSAILLES F-78035 VERSAILLES FRANCE
Titolo Testata:
Journal of Cell Science
, volume: 110, anno: 1997,
parte:, 4
pagine: 489 - 495
SICI:
0021-9533(1997)110:<489:DOAGPM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ICE-LIKE PROTEASES; MESSENGER-RNA; GAMMA-ACTIN; CELL-DEATH; BETA-ACTIN; DIFFERENTIAL DISPLAY; FLOW-CYTOMETRY; GROWTH-FACTOR; ACTIVATION; EXPRESSION;
Keywords:
APOPTOSIS; P53; SIMIAN VIRUS 40; MICROFILAMENT; ACTIN GENE; ICE-LIKE PROTEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
I. Guenal et al., "DOWN-REGULATION OF ACTIN GENES PRECEDES MICROFILAMENT NETWORK DISRUPTION AND ACTIN CLEAVAGE DURING P53-MEDIATED APOPTOSIS", Journal of Cell Science, 110, 1997, pp. 489-495

Abstract

Inactivation of Simian Virus 40 large T antigen, in cells immortalized with conditional mutants, leads to activation of p53 and apoptosis. We used the mRNA differential display method to identify genes differentially expressed during this process. We found that steady-state levels of mRNA for cytoplasmic actins decreased early during apoptosis, Wealso showed that, although the steady-state level of the corresponding proteins is not profoundly affected, they are substrates for an interleukin 1-beta converting enzyme (ICE)-like protease activated during the process, However, only a very small fraction of actin is proteolysed during the early stages of apoptosis. The microfilament network is affected and non polymerized actin accumulates in apoptotic bodies after the decrease of mRNA levels, but before a significant amount of actin is cleaved, This suggests that down-regulation of actin genes may be involved in microfilament rearrangements during p53-mediated apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:14:06