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Titolo:
INFLUENCE OF FRACTIONATED TOTAL-BODY IRRADIATION ON MUCOSAL TOXICITY IN INTENSIFIED CONDITIONING REGIMENS FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN PEDIATRIC CANCER-PATIENTS
Autore:
BORGMANN A; EMMINGER W; EMMINGERSCHMIDMEIER W; PETERS C; GATTERERMENZ I; HENZE G; GADNER H;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,HAMATOL ONKOL ABT,KINDERKLIN,REINICKENDORFER STR 61 D-13347 BERLIN GERMANY ST ANNA CHILDRENS HOSP VIENNA AUSTRIA
Titolo Testata:
Klinische Padiatrie
fascicolo: 4, volume: 206, anno: 1994,
pagine: 299 - 302
SICI:
0300-8630(1994)206:4<299:IOFTIO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOPHOSPHAMIDE; LEUKEMIA; CHEMORADIOTHERAPY; CHEMOTHERAPY; SURVIVORS; ETOPOSIDE; RADIATION; CHILDREN; BUSULFAN; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A. Borgmann et al., "INFLUENCE OF FRACTIONATED TOTAL-BODY IRRADIATION ON MUCOSAL TOXICITY IN INTENSIFIED CONDITIONING REGIMENS FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN PEDIATRIC CANCER-PATIENTS", Klinische Padiatrie, 206(4), 1994, pp. 299-302

Abstract

From April 1988 to March 1991 28 children with generalized solid tumors (N = 15) or hematologic malignancies (N = 13) received intensified myelotoxic regimens followed by autologous stem cell rescue (ABMT). These intensified regimens consisted of 12 Gy fractionated total body irradiation (FTBI) and 2 (or 3) cytotoxic drugs (group A, n = 19) or a combination of 3 cytotoxic drugs (group B, n = 9). FTBI-containing regimens produced more severe mucositis > = WHO grade 3 (p = 0.01) and a longer duration of severe mucositis. The mucositis had a median duration of 8 days (range 0-28) in group A compared with median 0 days (range0-7) in group B (p < 0.01). Acute renal and liver toxicity were not different. The probability of overall survival at day + 100 was 89% in all patients. In terms of long-term survival FTBI containing regimen did not prove superior: 5 out of 19 patients in group A and 6 out of 9 patients in group B have been survivors for a minimum of 3 years. In conclusion, severe gastrointestinal toxicity of such intensive regimensis avoidable if FTBI is omitted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:58:26