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Titolo:
IMPAIRED HEPATIC RETICULOENDOTHELIAL BACTERIAL CLEARANCE IN FETAL ANDNEWBORN RATS
Autore:
KATZ S; FOKENING WJ; GROSFELD JL;
Indirizzi:
MEIR HOSP,DEPT PEDIAT SURG,SAPIR MED CTR IL-44281 KEFAR SAVA ISRAEL
Titolo Testata:
Pediatric surgery international
fascicolo: 7, volume: 9, anno: 1994,
pagine: 471 - 473
SICI:
0179-0358(1994)9:7<471:IHRBCI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Keywords:
RETICULOENDOTHELIAL SYSTEM; BACTERIAL CLEARANCE; NEWBORN; FETAL RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S. Katz et al., "IMPAIRED HEPATIC RETICULOENDOTHELIAL BACTERIAL CLEARANCE IN FETAL ANDNEWBORN RATS", Pediatric surgery international, 9(7), 1994, pp. 471-473

Abstract

Sepsis is a major cause of morbidity and mortality in the neonate. This study evaluates the role of the hepatic reticuloendothelial system (RES) in removing blood-borne bacteria in fetal, newborn, and sucklingrats as compared to older rats. Sprague-Dawley rats were placed in four groups: group I (n = 8) were fetuses studied at hysterotomy at 20 days' gestation (body wt. 5.1+/-0.4 g), group II (n = 10) 2-week-old suckling (body wt. 33.4+/-3.2 g), group III (n = 10) 4-week-old (body wt. 68.3+/-5.4 g), and group IV (n = 10) 6-week weanling rats (body wt. 140+/6 g). S-35-radiolabeled viable Escherichia coli (10(9) bacteria/ml) was injected according to body weight via the tail vein in groups II, III, and IV and via the umbilical vein in group 1. At 10 min, bacterial distribution in the liver, spleen, kidneys, and lungs was determined. Tissue samples (50-100 mg) from each organ were processed for liquid scintillation counting. The final distribution of bacteria was calculated from the input specific activity (dpm/bacteria) and expressed as mean percentage of injected viable E. coli per g tissue and per total organ weight. The ability of the liver RES of fetal and neonatal rats to remove blood-borne bacteria was impaired (61.4+/-2, 53.8+/-8.2%,respectively) compared to controls (74.6+/-8.0, P<0.001). This was compensated for by an increase in lung localization of bacteria. The lung has a relatively poor capacity to kill sequestered bacteria, which may play a role in the occurrence of bacterial re-emergence and systemic sepsis in the neonate.

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Documento generato il 02/12/20 alle ore 18:15:55