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Titolo:
A CREATINE TRANSPORTER CDNA FROM TORPEDO ILLUSTRATES STRUCTURE-FUNCTION-RELATIONSHIPS IN THE GABA NORADRENALINE TRANSPORTER FAMILY
Autore:
GUIMBAL C; KILIMANN MW;
Indirizzi:
RUHR UNIV BOCHUM,FAK MED,INST PHYSIOL CHEM D-44780 BOCHUM GERMANY RUHR UNIV BOCHUM,FAK MED,INST PHYSIOL CHEM D-44780 BOCHUM GERMANY
Titolo Testata:
Journal of Molecular Biology
fascicolo: 2, volume: 241, anno: 1994,
pagine: 317 - 324
SICI:
0022-2836(1994)241:2<317:ACTCFT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN GABA TRANSPORTER; RAT-BRAIN; NEUROTRANSMITTER TRANSPORTERS; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; MOUSE-BRAIN;
Keywords:
CREATINE; NEUROTRANSMITTER TRANSPORTER; TORPEDO; PLASMA MEMBRANE TRANSPORT; SYNAPSE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
C. Guimbal e M.W. Kilimann, "A CREATINE TRANSPORTER CDNA FROM TORPEDO ILLUSTRATES STRUCTURE-FUNCTION-RELATIONSHIPS IN THE GABA NORADRENALINE TRANSPORTER FAMILY", Journal of Molecular Biology, 241(2), 1994, pp. 317-324

Abstract

A family of homologous, Na+/Cl- dependent plasma membrane transporters catalyze the uptake of a number of neurotransmitters and structurally related compounds into cells. Here, we report the cDNA cloning, sequencing and functional characterization of a nonmammalian member of this transporter family. A creatine transporter from the electric ray, Torpedo marmorata, displays 64% amino acid identity with its rabbit counterpart and has a similar substrate affinity and specificity. Sequencesimilarity generally is lowest in those regions where also the sequences of other members of the family, transporting different substrates,diverge. Only a few amino acids are better conserved between the two creatine transporters than with the other family members and are candidates for a role in conferring substrate specificity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:10:35