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Titolo:
COMPARATIVE ASPECTS OF PLACENTAL LACTOGENS - STRUCTURE AND FUNCTION
Autore:
FORSYTH IA;
Indirizzi:
BABRAHAM INST,DEPT CELLULAR PHYSIOL,BABRAHAM HALL CAMBRIDGE CB2 4AT CAMBS ENGLAND
Titolo Testata:
Experimental and clinical endocrinology
fascicolo: 3, volume: 102, anno: 1994,
pagine: 244 - 251
SICI:
0232-7384(1994)102:3<244:CAOPL->2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC SOMATOMAMMOTROPIN; GROWTH FACTOR-I; HUMAN-FETAL FIBROBLASTS; DNA-SYNTHESIS; MAMMARY GROWTH; LATE-GESTATION; MID-PREGNANCY; SOMATOMEDIN-C; BREAST TUMORS; SHEEP LIVER;
Keywords:
PLACENTAL LACTOGENS; MAMMOGENESIS; NUTRIENT PARTITIONING; FETAL GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
I.A. Forsyth, "COMPARATIVE ASPECTS OF PLACENTAL LACTOGENS - STRUCTURE AND FUNCTION", Experimental and clinical endocrinology, 102(3), 1994, pp. 244-251

Abstract

Removal of the pituitary from pregnant rats provided early evidence that the placenta was the source of prolactin-like bioactivity. After mid-pregnancy the placenta was able to support progesterone production by the corpus luteum (luteotrophic activity) and continued developmentof the mammary gland (mammotrophic activity). Three groups of mammals, the rodents, the ruminant artiodactyls and the primates are now known to produce from fetal placenta a remarkable variety of proteins which are related in structure to pituitary prolactin and growth hormone. Prolactin and growth hormone are themselves structurally related and are thought to have arisen from a common ancestral gene by gene duplication and evolutionary divergence. The receptors with which they interact also form a family of homologous proteins. Surprisingly the placental lactogens appear to have arisen more than once in evolution since in primates they are structurally closely related to growth hormone, while in rodents and ruminants they have closer similarity to prolactin. There is suggestive evidence that there may be specific receptors forplacental lactogens in some fetal and maternal tissues. In humans a five-gene cluster on chromosome 17 contains two growth hormone (GH) andthree placental lactogen (PL) genes. Two human PL genes encode identical proteins that are expressed in the placenta. One of the human GH genes is also placentally expressed. In mice, chromosome 13 carries thegenes for mouse prolactin, for placental lactogen-I and -II (PL-I andPL-II) and for two other prolactin-related proteins, the proliferins. Rats also express PL-I and PL-II, together with at least three other placental prolactin-like proteins different from proliferins. In sheep, goat and cow, placental lactogens with about 50% sequence homology with their homologous prolactins occur. The bovine placenta has also yielded cDNA clones predicting proteins related to prolactin but distinct from FL. The physiological role of most of these known or predicted proteins is poorly understood. Each, however, appears to show a ratherspecific pattern of expression with regard to tissue, cell and time of appearance. Placental lactogens may reach very high concentrations in maternal plasma and their roles are thought to include luteotrophic effects in rodents and in all species metabolic effects to divert nutrients to the fetus as well as effects on mammary development. They mayalso have important roles in the fetus exerting growth-promoting and metabolic actions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:49:13