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Titolo:
DENDRITIC PATHOLOGY OF GRANULE CELLS IN ALZHEIMERS-DISEASE IS UNRELATED TO NEURITIC PLAQUES
Autore:
EINSTEIN G; BURANOSKY R; CRAIN BJ;
Indirizzi:
DUKE UNIV,MED CTR,DEPT NEUROBIOL,BOX 3209 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PATHOL DURHAM NC 27710
Titolo Testata:
The Journal of neuroscience
fascicolo: 8, volume: 14, anno: 1994,
pagine: 5077 - 5088
SICI:
0270-6474(1994)14:8<5077:DPOGCI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID BETA-PROTEIN; SENILE DEMENTIA; NEUROFIBRILLARY TANGLES; CORTICAL-NEURONS; CEREBRAL-CORTEX; FASCIA DENTATA; NEUROTOXICITY; PATHWAY; GOLGI; RAT;
Keywords:
BETA-AMYLOID; HIPPOCAMPUS; DENDRITIC MORPHOLOGY; LIGHTLY FIXED SLICE; DENTATE GYROS; DYSTROPHIC NEURITES; INTRACELLULAR INJECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G. Einstein et al., "DENDRITIC PATHOLOGY OF GRANULE CELLS IN ALZHEIMERS-DISEASE IS UNRELATED TO NEURITIC PLAQUES", The Journal of neuroscience, 14(8), 1994, pp. 5077-5088

Abstract

Neuritic plaques are the histologic hallmark of Alzheimer's disease (AD); however, the extent to which they are injurious to neurons is unclear. In order to investigate this problem, we intracellularly filled human dentate granule cells with Lucifer yellow in a lightly fixed slice preparation and studied the relationships between their dendrites and neuritic plaques. After counterstaining for plaques and drawing thefilled granule cell dendrites, we found that there were significant differences in the morphology of dendrites in control and AD cases; granule cell dendrites from Alzheimer's cases were generally shorter, branched less profusely, and had fewer spines than those from age matchedcontrols. Surprisingly, when dendrites traveled into plaques, they still bore spines and their morphology was distinct from that of the amyloid-stained dystrophic neurites surrounding them. Furthermore, withinAD cases we found no significant differences between dendrites that were located directly beneath or passing through plaques and those thatwere located in plaque-free regions. We conclude that granule cell dendrites are not an integral component of plaques within their dendritic fields and that neuritic plaques have no direct effect on granule cells in the dentate gyrus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:34:55