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Titolo:
SERUM LEVELS OF SOLUBLE ADHESION MOLECULES INTERCELLULAR-ADHESION MOLECULE-1, VASCULAR CELL-ADHESION MOLECULE-1, AND E-SELECTIN IN PATIENTSWITH WEGENERS GRANULOMATOSIS - RELATIONSHIP TO DISEASE-ACTIVITY AND RELEVANCE DURING FOLLOW-UP
Autore:
STEGEMAN CA; TERVAERT JWC; HUITEMA MG; DEJONG PE; KALLENBERG CGM;
Indirizzi:
UNIV GRONINGEN HOSP,DEPT MED,DIV NEPHROL,OOSTERSINGEL 59 9713 EZ GRONINGEN NETHERLANDS
Titolo Testata:
Arthritis and rheumatism
fascicolo: 8, volume: 37, anno: 1994,
pagine: 1228 - 1235
SICI:
0004-3591(1994)37:8<1228:SLOSAM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; CYTOPLASMIC ANTIBODY TITER; TUMOR-NECROSIS-FACTOR; LEUKOCYTE ADHESION; RHEUMATOID-ARTHRITIS; ENDOTHELIAL-CELLS; CIRCULATING ICAM-1; INTERFERON-GAMMA; EXPRESSION; VCAM-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Stegeman et al., "SERUM LEVELS OF SOLUBLE ADHESION MOLECULES INTERCELLULAR-ADHESION MOLECULE-1, VASCULAR CELL-ADHESION MOLECULE-1, AND E-SELECTIN IN PATIENTSWITH WEGENERS GRANULOMATOSIS - RELATIONSHIP TO DISEASE-ACTIVITY AND RELEVANCE DURING FOLLOW-UP", Arthritis and rheumatism, 37(8), 1994, pp. 1228-1235

Abstract

Objective. To assess the value of measuring serum levels of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble E-selectin for monitoring disease activity in Wegener's granulomatosis (WG). Methods. A sandwich enzyme-linked immunosorbent assay was used to measure levels of soluble adhesion molecules at the time of diagnosis in 22 consecutive patients with WG, in 12 WG patients studied serially prior to disease relapse, at the time of upper airways infection in 18 patients with inactive WG,and in 57 controls. Disease activity was assessed by disease activityscore and C-reactive protein levels. Results. At diagnosis of WG, sICAM-1 and sVCAM-1 levels were significantly elevated and correlated with disease activity. At the time of relapse, a significant increase in all 3 soluble adhesion molecules was found compared with levels at 6 months prior to relapse, but only sVCAM-1 levels were significantly elevated compared with those in controls. Levels of soluble adhesion molecules at the time of relapse did not differ from those measured duringan upper airways infection without disease activity. Conclusion. Elevated serum levels of sICAM-1 and sVCAM-1 can be found in active WG andcorrelate with disease activity. However, their clinical relevance for followup is limited due to lack of sensitivity and specificity for WG disease activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:51:13