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Titolo:
THE IMMUNOSUPPRESSORY AND ADHESIVE MINIREGION OF THE HUMAN MAJOR HISTOCOMPATIBILITY PROTEIN, HUMAN-LEUKOCYTE ANTIGEN DQ
Autore:
SZEWCZUK Z; STEFANOWICZ P; WILCZYNSKI A; SIEMION IZ; CIERNIEWSKI CS; KRALISZ U; WIECZOREK Z;
Indirizzi:
WROCLAW B BEIRUT UNIV,DEPT CHEM,F JOLIOT CURIE 14 PL-50383 WROCLAW POLAND MED UNIV LODZ,INST PHYSIOL & BIOCHEM PL-90131 LODZ POLAND POLISH ACAD SCI,INST IMMUNOL & EXPT THERAPY PL-53114 WROCLAW POLAND
Titolo Testata:
Biopolymers
fascicolo: 5, volume: 40, anno: 1996,
pagine: 571 - 583
SICI:
0006-3525(1996)40:5<571:TIAAMO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RGD PEPTIDES; THYMOPENTIN; FIBRONECTIN; INTEGRINS; CELLS;
Keywords:
HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II, THYMOPENTIN ANALOGS; IMMUNOSUPPRESSORS; RGD SEQUENCE, INTEGRINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Z. Szewczuk et al., "THE IMMUNOSUPPRESSORY AND ADHESIVE MINIREGION OF THE HUMAN MAJOR HISTOCOMPATIBILITY PROTEIN, HUMAN-LEUKOCYTE ANTIGEN DQ", Biopolymers, 40(5), 1996, pp. 571-583

Abstract

Our previous studies showed that the nonapeptide fragment of human leukocyte antigen DQ with TPQRGDVYT sequence strongly suppresses the immune response(1) [Z. Szewczuk, I.Z. Siemion, and Z. Wieczorek (1996) Molecular Immunology, 33, 903-908]. The fragment contains the RGDVY sequence, which is very similar to thymopentin (pentapeptide RKDVY, an active fragment (32-26) of thymopoietin, an immune system activator produced in thymi), and at the same time contains the RGD sequence, known as an inhibitor of adhesion processes. In the present study we tested an influence of the nonapeptide and its shorter fragments on binding ofactivated platelets and K562 cells to fibrinogen and fibronectin, respectively. We also designed and synthesized a cyclic thymopentin-like peptide, CRGDVYC* (where C* indicates Cys participating in disulfide bridge) to restrict its conformation. The cyclization product stronglysuppresses the humoral and cellular immune response and selectively inhibits the adhesion of K562 cells to fibronectin. The results are discussed in the light of CD conformational studies. (C) 1997 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:55:32